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临床泌尿生殖系统样本中新型微生物的存在及相关性

Presence and Relevance of Emerging Microorganisms in Clinical Genitourinary Samples.

作者信息

Rosales-Castillo Antonio, Expósito-Ruiz Manuela, Gutiérrez-Soto Miguel, Navarro-Marí José María, Gutiérrez-Fernández José

机构信息

Department of Internal Medicine, Virgen de las Nieves University Hospital and Doctoral Program of Clinical Medicine and Public Health, University of Granada, Granada Institute of Biohealth Research (Ibs.), Avda. de las Fuerzas Armadas 2, 18014 Granada, Spain.

Biostatistics Unit, Department of Statistics, School of Medicine, University of Granada, 18012 Granada, Spain.

出版信息

Microorganisms. 2023 Mar 31;11(4):915. doi: 10.3390/microorganisms11040915.

Abstract

Microorganisms responsible for genitourinary infections increasingly include species other than conventional etiological agents that are of clinical and pathogenic relevance and therapeutic interest. This cross-sectional descriptive study selected samples from clinical genitourinary episodes between January 2016 and December 2019 in which emerging microbiological agents were detected. The patients' epidemiological characteristics, clinical presentation, antibiotic treatment, and outcome were studied to identify their pathogenic role. The emerging microorganisms most frequently detected in urinary tract infections were (58.5%) and spp. (23.6%) in females and (32.3%), (18.6%), and spp. (16.9%) in males, while the most frequently detected in genital infections were (36.4%) in females and (32.2%) and spp. (35.6%) in males. All cases in female children were produced by Symptomatic episodes were more frequent with spp. and and the presence of leukocytosis more frequent with spp. Quinolones and doxycycline were most often prescribed antibiotics for genital infections and quinolones and amoxicillin-clavulanic acid for urinary infections. Urinary infection by spp. was more frequent in males of advanced age, spp. was more frequent in permanent vesical catheter carriers, and episodes of asymptomatic bacteriuria by spp. were more frequent in patients with kidney transplant and chronic consumers of corticosteroid therapy. spp. should be considered in urinary infections of patients of advanced age and with a previous antibiotic load. Genital infection by spp. was significantly associated with a history of risky sexual relations.

摘要

引起泌尿生殖系统感染的微生物越来越多地包括除传统病原体之外的其他物种,这些物种具有临床和致病相关性以及治疗意义。这项横断面描述性研究选取了2016年1月至2019年12月期间临床泌尿生殖系统疾病发作的样本,这些样本中检测到了新出现的微生物病原体。研究了患者的流行病学特征、临床表现、抗生素治疗及治疗结果,以确定这些病原体的致病作用。在女性尿路感染中最常检测到的新出现微生物是 (58.5%)和 属(23.6%),在男性中是 (32.3%)、 (18.6%)和 属(16.9%);而在生殖器感染中最常检测到的,女性是 (36.4%),男性是 (32.2%)和 属(35.6%)。女童的所有病例均由 引起。 属和 引起的症状性发作更为常见,而 属感染时白细胞增多更为常见。喹诺酮类药物和强力霉素是生殖器感染最常开具的抗生素,喹诺酮类药物和阿莫西林 - 克拉维酸是尿路感染最常开具的抗生素。 属引起的尿路感染在老年男性中更为常见, 属在永久性膀胱导管携带者中更为常见, 属引起的无症状菌尿症在肾移植患者和长期使用皮质类固醇治疗的患者中更为常见。对于老年患者和既往有抗生素使用史的患者的尿路感染,应考虑 属感染。 属引起的生殖器感染与危险性关系史显著相关。

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本文引用的文献

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The urobiome in men and women: a clinical review.男性和女性的尿生殖微生物组:临床综述。
Clin Microbiol Infect. 2023 Oct;29(10):1242-1248. doi: 10.1016/j.cmi.2022.08.010. Epub 2022 Aug 24.
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An Uncommon Cause of Urinary Tract Infections: A Case Report.尿路感染的罕见病因:一例报告
Cureus. 2022 Mar 19;14(3):e23325. doi: 10.7759/cureus.23325. eCollection 2022 Mar.

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