感谢酵母，高迁移率族蛋白从酵母到癌症的历史。

Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer.

作者信息

Lamas-Maceiras Mónica, Vizoso-Vázquez Ángel, Barreiro-Alonso Aida, Cámara-Quílez María, Cerdán María Esperanza

机构信息

Centro Interdisciplinar de Química y Biología (CICA), As Carballeiras, s/n, Campus de Elviña, Universidade da Coruña, 15071 A Coruña, Spain.

Instituto de Investigación Biomédica de A Coruña (INIBIC), As Xubias de Arriba 84, 15006 A Coruña, Spain.

出版信息

Microorganisms. 2023 Apr 11;11(4):993. doi: 10.3390/microorganisms11040993.

DOI:10.3390/microorganisms11040993

PMID:37110415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10142021/

Abstract

Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of eukaryotic cells as soon as the techniques of molecular biology developed. Our molecular understandings of metabolism, cellular transport, DNA repair, gene expression and regulation, and the cell division cycle have all been obtained through biochemistry and genetic analysis using different yeasts. In this review, we summarize the role that yeasts have had in biological discoveries, the use of yeasts as biological tools, as well as past and on-going research projects on HMGB proteins along the way from yeast to cancer.

摘要

自古以来，酵母就在许多用于食品的天然产物发酵中成为人类生活的一部分。此外，在20世纪，随着分子生物学技术的发展，酵母很快成为阐明真核细胞功能的有力工具。我们对代谢、细胞运输、DNA修复、基因表达与调控以及细胞分裂周期的分子理解均通过使用不同酵母的生物化学和遗传分析而获得。在这篇综述中，我们总结了酵母在生物学发现中所起的作用、酵母作为生物工具的用途，以及从酵母到癌症过程中关于高迁移率族蛋白（HMGB）的过往和正在进行的研究项目。