Division of Colorectal Surgery, Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 442-723, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon 442-723, Republic of Korea.
Nutrients. 2023 Apr 19;15(8):1966. doi: 10.3390/nu15081966.
Colorectal cancer diagnosed in individuals under 50 years old is called early-onset colorectal cancer (EOCRC), and its incidence has been rising worldwide. Simultaneously occurring with increasing obesity, this worrisome trend is partly explained by the strong influence of dietary elements, particularly fatty, meaty, and sugary food. An animal-based diet, the so-called Western diet, causes a shift in dominant microbiota and their metabolic activity, which may disrupt the homeostasis of hydrogen sulfide concentration. Bacterial sulfur metabolism is recognized as a critical mechanism of EOCRC pathogenesis. This review evaluates the pathophysiology of how a diet-associated shift in gut microbiota, so-called the microbial sulfur diet, provokes injuries and inflammation to the colonic mucosa and contributes to the development of CRC.
在 50 岁以下人群中诊断出的结直肠癌称为早发性结直肠癌（EOCRC），其发病率在全球范围内呈上升趋势。随着肥胖的同时发生，这种令人担忧的趋势部分归因于饮食因素的强烈影响，特别是高脂肪、肉类和含糖食物。基于动物的饮食，即所谓的西方饮食，会导致优势微生物及其代谢活性发生转变，这可能破坏硫化氢浓度的体内平衡。细菌硫代谢被认为是 EOCRC 发病机制的关键机制。本综述评估了饮食相关的肠道微生物群转变（所谓的微生物硫饮食）如何引发结肠黏膜损伤和炎症，并促进 CRC 发展的病理生理学。
