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深海矿泉滋养桑黄子实体发酵物通过抑制氧化炎性因子和衰老相关风险因素预防 D-半乳糖诱导的记忆损伤。

NTTU 868 Mycelia Fermented with Deep Ocean Water Minerals Prevents D-Galactose-Induced Memory Deficits by Inhibiting Oxidative Inflammatory Factors and Aging-Related Risk Factors.

机构信息

Marine Industry and Engineer Research Center, National Academy of Marine Research, Kaohsiung 806614, Taiwan.

Department of Life Science, National Taitung University, 369, Section 2, University Rd., Taitung 95092, Taiwan.

出版信息

Nutrients. 2023 Apr 19;15(8):1968. doi: 10.3390/nu15081968.

DOI:10.3390/nu15081968
PMID:37111188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10145131/
Abstract

, a medicinal fungus that is abundant in bioactive compounds such as N6-(2-hydroxyethyl)-adenosine (HEA) and polysaccharides, possesses remarkable anti-inflammatory, antioxidant, and nerve damage recovery properties. Deep ocean water (DOW) contains minerals that can be absorbed and transformed into organic forms by fungi fermentation. Recent studies have shown that culturing in DOW can enhance its therapeutic benefits by increasing the levels of bioactive compounds and minerals' bioavailibility. In this study, we investigated the effects of DOW-cultured (DCC) on brain damage and memory impairment induced by D-galactose in rats. Our results indicate that DCC and its metabolite HEA can improve memory ability and exhibit potent antioxidant activity and free radical scavenging in D-galactose-induced aging rats ( < 0.05). Additionally, DCC can mitigate the expression of inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS), thereby preventing brain aging. Furthermore, DCC showed a significant decrease in the expression of the aging-related proteins glial fibrillary acidic protein (GFAP) and presenilin 1 (PS1). By reducing brain oxidation and aging-related factors, DOW-cultured demonstrate enhanced anti-inflammatory, antioxidant, and neuroprotective effects, making it a promising therapeutic agent for preventing and treating age-related brain damage and cognitive impairment.

摘要

蛹虫草是一种富含 N6-(2-羟乙基)-腺苷（HEA）和多糖等生物活性化合物的药用真菌，具有显著的抗炎、抗氧化和神经损伤恢复特性。深海水（DOW）含有矿物质，这些矿物质可以通过真菌发酵被吸收并转化为有机形式。最近的研究表明，在 DOW 中培养 可以通过增加生物活性化合物和矿物质的生物利用度来增强其治疗效果。在这项研究中，我们研究了 DOW 培养的蛹虫草（DCC）对 D-半乳糖诱导的大鼠脑损伤和记忆障碍的影响。我们的结果表明，DCC 及其代谢物 HEA 可以改善记忆能力，在 D-半乳糖诱导的衰老大鼠中表现出强大的抗氧化活性和自由基清除活性（<0.05）。此外，DCC 可以减轻炎症因子的表达，如肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、环氧化酶-2（COX-2）和诱导型一氧化氮合酶（iNOS），从而预防大脑衰老。此外，DCC 还显著降低了与衰老相关的蛋白胶质纤维酸性蛋白（GFAP）和早老素 1（PS1）的表达。通过降低大脑氧化和衰老相关因素，DOW 培养的蛹虫草表现出增强的抗炎、抗氧化和神经保护作用，使其成为预防和治疗与年龄相关的大脑损伤和认知障碍的有前途的治疗剂。

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