Molluscicidal and Larvicidal Potency of -Heterocylic Analogs against Snails and Larval Stages.

This work describes the synthesis of quinoline-based --heterocyclic arenes and their biological evaluation as molluscicides against adult snails as well as larvicides against larvae (miracidia and cercariae). Molecular docking studies were demonstrated to investigate their affinity for cysteine protease protein as an interesting target for antiparasitics. Compound showed the best docking results followed by in comparison to the co-crystallized ligand D1R reflected by their binding affinities and RMSD values. The egg production, hatchability of snails and ultrastructural topography of cercariae using SEM were assessed. Biological evaluations (hatchability and egg-laying capacity) revealed that the quinoline hydrochloride salt was the most effective compound against adult snails, whereas the indolo-quinoline derivative had the most efficiency against miracidia, and the acridinyl derivative was the most effective against cercariae and caused 100% mortality. and were found to modulate the biological responses of snails with/without infection and larval stages that will affect infection. caused deleterious morphological effects on cercariae. caused inhibition in the number of eggs/snail/week and reduced reproductive rate to 43.8% in all the experimental groups. and can be recommended as an effective molluscicide of plant origin for the control program of schistosomiasis.