Udugampolage Nathasha Samali, Pini Alessandro, Magon Arianna, Conte Gianluca, Callus Edward, Taurino Jacopo, Caruso Rosario
Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Health Professions Research and Development Unit, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Vaccines (Basel). 2023 Mar 26;11(4):734. doi: 10.3390/vaccines11040734.
Although vaccine hesitancy has been reported in many patient groups and countries, there is a lack of data on vaccine hesitancy in patients with Marfan syndrome (MFS). MFS is a rare genetic disorder that can lead to cardiovascular, ocular, and musculoskeletal issues. Because MFS patients may face an increased risk of COVID-19 complications, vaccination is crucial for this population. This brief report aims to describe vaccine hesitancy rates in MFS patients and compare the characteristics of patients who are hesitant and those who are not to gain a better understanding of this specific population. This study analyzes previously published cross-sectional data that examined mental health, sociodemographic, and clinical factors associated with PTSD, depression, anxiety, and insomnia in MFS patients during the third wave of the COVID-19 pandemic in Lombardy, Italy. Of the 112 MFS patients who participated, 26 (23.9%) reported vaccine hesitancy. Vaccine hesitancy may be associated mainly with younger age and not be related to other patient characteristics. Therefore, this report found no differences in individual-level variables, such as sex, education, comorbidities, and mental health symptoms, between those who were hesitant and those who were not. The study findings are insightful and suggest that interventions to address vaccine hesitancy in this population may need to focus on attitudes and beliefs related to vaccination rather than targeting specific sociodemographic or clinical factors.
尽管在许多患者群体和国家都有疫苗犹豫的报道，但关于马凡综合征（MFS）患者的疫苗犹豫情况却缺乏数据。MFS是一种罕见的遗传性疾病，可导致心血管、眼部和肌肉骨骼问题。由于MFS患者可能面临新冠并发症风险增加，接种疫苗对这一人群至关重要。本简要报告旨在描述MFS患者的疫苗犹豫率，并比较犹豫和不犹豫患者的特征，以便更好地了解这一特定人群。本研究分析了此前发表的横断面数据，这些数据调查了意大利伦巴第大区新冠疫情第三波期间MFS患者中与创伤后应激障碍（PTSD）、抑郁、焦虑和失眠相关的心理健康、社会人口统计学和临床因素。在参与研究的112名MFS患者中，26名（23.9%）报告有疫苗犹豫。疫苗犹豫可能主要与年龄较小有关，与其他患者特征无关。因此，本报告发现，犹豫和不犹豫的患者在个体层面变量上没有差异，如性别、教育程度、合并症和心理健康症状。该研究结果具有启发性，表明针对这一人群解决疫苗犹豫问题的干预措施可能需要侧重于与疫苗接种相关的态度和信念，而不是针对特定的社会人口统计学或临床因素。
