Division of Ruminant Medicine, Department of Clinical Sciences, Swedish University of Agriculture Sciences, 8 Almas Allé, 75007 Uppsala, Sweden.
Department of Microbiology, National Veterinary Institute, Ulls väg 2B, 75189 Uppsala, Sweden.
Viruses. 2023 Mar 24;15(4):829. doi: 10.3390/v15040829.
Influenza D virus (IDV) has been detected in bovine respiratory disease (BRD) outbreaks, and experimental studies demonstrated this virus's capacity to cause lesions in the respiratory tract. In addition, IDV-specific antibodies were detected in human sera, which indicated that this virus plays a potential zoonotic role. The present study aimed to extend our knowledge about the epidemiologic situation of IDV in Swedish dairy farms, using bulk tank milk (BTM) samples for the detection of IDV antibodies. A total of 461 and 338 BTM samples collected during 2019 and 2020, respectively, were analyzed with an in-house indirect ELISA. In total, 147 (32%) and 135 (40%) samples were IDV-antibody-positive in 2019 and 2020, respectively. Overall, 2/125 (2%), 11/157 (7%) and 269/517 (52%) of the samples were IDV-antibody-positive in the northern, middle and southern regions of Sweden. The highest proportion of positive samples was repeatedly detected in the south, in the county of Halland, which is one of the counties with the highest cattle density in the country. In order to understand the epidemiology of IDV, further research in different cattle populations and in humans is required.
牛呼吸道疾病（BRD）暴发中已检测到 D 型流感病毒（IDV），实验研究表明该病毒有能力引起呼吸道病变。此外，在人类血清中检测到了 IDV 特异性抗体，这表明该病毒具有潜在的人畜共患病作用。本研究旨在利用批量奶（BTM）样本检测 IDV 抗体，进一步了解瑞典奶牛场 IDV 的流行情况。
分别用 2019 年和 2020 年采集的 461 份和 338 份 BTM 样本，使用内部间接 ELISA 进行分析。在 2019 年和 2020 年，分别有 147（32%）和 135（40%）的样本 IDV 抗体阳性。总的来说，瑞典北部、中部和南部地区 2/125（2%）、11/157（7%）和 269/517（52%）的样本 IDV 抗体阳性。阳性样本比例最高的地区是南部的 Halland 县，该县是该国牛密度最高的县之一。
为了了解 IDV 的流行病学情况，需要在不同的牛群和人群中开展进一步的研究。
