牛呼吸道疾病综合征中七节段流感病毒的流行情况及特征。
Prevalence and characterization of seven-segmented influenza viruses in bovine respiratory disease complex.
机构信息
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, 40546, USA.
Department of Veterinary and Biomedical Science, South Dakota State University, Brookings, SD, 57007, USA.
出版信息
Virology. 2023 Oct;587:109859. doi: 10.1016/j.virol.2023.109859. Epub 2023 Aug 3.
Bovine respiratory disease (BRD) complex is a multifactorial respiratory disease of cattle. Seven-segmented influenza C (ICV) and D (IDV) viruses have been identified in cattle with BRD, however, molecular epidemiology and prevalence of IDV and ICV in the diseased population remain poorly characterized. Here, we conducted a molecular screening of 208 lung samples of bovine pneumonia cases for the presence of IDV and ICV. Our results demonstrated that both viruses were prevalent in BRD cases and the overall positivity rates of IDV and ICV were 20.88% and 5.99% respectively. Further analysis of three IDV strains isolated from lungs of cattle with BRD showed that these lung-tropic strains belonged to D/Michigan/2019 clade and diverged antigenically from the circulating dominant IDV clades D/OK and D/660. Our results reveal that IDV and ICV are associated with BRD complex and support a role for IDV and ICV in the etiology of BRD.
牛呼吸道疾病（BRD）综合征是一种多因素引起的牛呼吸道疾病。在患有 BRD 的牛中已鉴定出具有七个节段的 C 型流感（ICV）和 D 型流感（IDV）病毒，然而，IDV 和 ICV 在患病群体中的分子流行病学和流行情况仍未得到很好的描述。在这里，我们对 208 个牛肺炎病例的肺样本进行了 IDV 和 ICV 的分子筛选。我们的结果表明，这两种病毒在 BRD 病例中均普遍存在，IDV 和 ICV 的总阳性率分别为 20.88%和 5.99%。对从患有 BRD 的牛肺部分离出的三种 IDV 株的进一步分析表明，这些肺嗜性株属于 D/Michigan/2019 分支，与流行的 IDV 优势分支 D/OK 和 D/660 在抗原上存在差异。我们的研究结果表明，IDV 和 ICV 与 BRD 综合征相关，并支持 IDV 和 ICV 在 BRD 病因学中的作用。
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