Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi 208-0011, Tokyo, Japan.
Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, 1-2 Hachimandai, Tsukuba 305-0843, Ibaraki, Japan.
Viruses. 2023 Mar 31;15(4):903. doi: 10.3390/v15040903.
Poliovirus (PV) is the causative agent of poliomyelitis and is a target of the global eradication programs of the World Health Organization (WHO). After eradication of type 2 and 3 wild-type PVs, vaccine-derived PV remains a substantial threat against the eradication as well as type 1 wild-type PV. Antivirals could serve as an effective means to suppress the outbreak; however, no anti-PV drugs have been approved at present. Here, we screened for effective anti-PV compounds in a library of edible plant extracts (a total of 6032 extracts). We found anti-PV activity in the extracts of seven different plant species. We isolated chrysophanol and vanicoside B (VCB) as the identities of the anti-PV activities of the extracts of and , respectively. VCB targeted the host PI4KB/OSBP pathway for its anti-PV activity (EC = 9.2 μM) with an inhibitory effect on in vitro PI4KB activity (IC = 5.0 μM). This work offers new insights into the anti-PV activity in edible plants that may serve as potent antivirals for PV infection.
脊灰病毒（PV）是脊髓灰质炎的病原体，也是世界卫生组织（WHO）全球根除计划的目标。在消灭 2 型和 3 型野生型 PV 之后，疫苗衍生的 PV 仍然是根除以及 1 型野生型 PV 的重大威胁。抗病毒药物可以作为抑制疫情的有效手段；然而，目前尚无抗 PV 药物获得批准。在这里，我们在食用植物提取物文库（共 6032 种提取物）中筛选了有效的抗 PV 化合物。我们发现七种不同植物的提取物具有抗 PV 活性。我们分离出大黄素和香草酸 B（VCB），分别作为 和提取物的抗 PV 活性的物质基础。VCB 针对宿主 PI4KB/OSBP 途径发挥抗 PV 活性（EC = 9.2 μM），对体外 PI4KB 活性具有抑制作用（IC = 5.0 μM）。这项工作为食用植物的抗 PV 活性提供了新的见解，这些活性可能成为抗 PV 感染的有效抗病毒药物。
