Yao Baodong, Lu Xiaojing, Xu Lai, Jiang Yun
Department of Performance Management, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Nutr. 2023 Apr 11;10:1141156. doi: 10.3389/fnut.2023.1141156. eCollection 2023.
Folate was involved in oxidative stress, hepatic lipid metabolism and chronic hepatic inflammation. However, evidence about the association between serum folate level and non-alcoholic fatty liver disease (NAFLD) in general population is scarce. This study aimed to explore the relationship between serum folate level and NAFLD among adults.
7,146 adult participants aged 20 years and over who have complete data of serum folate level and liver function biomarkers in NHANES 2011-2018 were included. Serum folate level was measured by isotope-dilution high-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). And suspected NAFLD was defined according to the United States fatty liver index (USFLI). Logistic regression and the restricted cubic spline models were performed.
Serum folate level was inversely associated with the presence of NAFLD. When comparing the second, third and fourth quartiles of serum folate level to the lowest quartile, the adjusted ORs of the presence of NAFLD were 0.62 (0.49-0.78), 0.65 (0.51-0.84), and 0.43 (0.32-0.56) respectively ( for trend<0.001). The non-linear and L-shaped relationship was found between serum folate level and the presence of NAFLD in the restricted cubic spline regression ( for non-linearity <0.01). Consistent with serum total folate, serum 5-Methyltetrahydrofolate level was also inversely associated with the presence of NAFLD.
Higher serum folate level may be negatively associated with NAFLD.
叶酸参与氧化应激、肝脏脂质代谢和慢性肝脏炎症。然而，关于普通人群血清叶酸水平与非酒精性脂肪性肝病（NAFLD）之间关联的证据稀少。本研究旨在探讨成人血清叶酸水平与NAFLD之间的关系。
纳入了2011 - 2018年美国国家健康与营养检查调查（NHANES）中7146名年龄在20岁及以上且有血清叶酸水平和肝功能生物标志物完整数据的成年参与者。血清叶酸水平通过同位素稀释高效液相色谱 - 串联质谱法（LC - MS/MS）测定。疑似NAFLD根据美国脂肪肝指数（USFLI）定义。进行了逻辑回归和受限立方样条模型分析。
血清叶酸水平与NAFLD的存在呈负相关。将血清叶酸水平的第二、第三和第四四分位数与最低四分位数进行比较时，NAFLD存在的校正比值比分别为0.62（0.49 - 0.78）、0.65（0.51 - 0.84）和0.43（0.32 - 0.56）（趋势P<0.001）。在受限立方样条回归中发现血清叶酸水平与NAFLD的存在呈非线性和L形关系（非线性P<0.01）。与血清总叶酸一致，血清5 - 甲基四氢叶酸水平也与NAFLD的存在呈负相关。
较高的血清叶酸水平可能与NAFLD呈负相关。
