Endocrinology Division, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Nutrients. 2020 Dec 17;12(12):3860. doi: 10.3390/nu12123860.
Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie intake with or without specific macronutrient adjustments. Furthermore, other relevant nutritional interventions are built on food selection and time-restricted eating. Since every strategy might bring different results, choosing the optimal diet therapy for a patient is a complicated task, because NAFLD is a multifactorial complex disease. Importantly, some factors need to be considered, such as nutrition-based evidence in terms of hepatic morphophysiological improvements as well as adherence of the patient to the meal plan and adaptability in their cultural context. Thus, the purpose of this review is to explore and compare the subtleties and nuances of the most relevant clinical practice guidelines and the nutritional approaches for the management of NAFLD with a special attention to tangible outcomes and long-term adherence.
非酒精性脂肪性肝病（NAFLD）在全球范围内呈上升趋势，是一个公共卫生问题。它与肥胖和其他代谢异常的共存率非常高。因此，目前针对 NAFLD 的治疗干预主要集中在通过调节总热量摄入来逐步减轻体重，无论是否进行特定的宏量营养素调整。此外，其他相关的营养干预措施是基于食物选择和限时进食。由于每种策略可能带来不同的结果，因此为患者选择最佳的饮食疗法是一项复杂的任务，因为 NAFLD 是一种多因素的复杂疾病。重要的是，需要考虑一些因素，例如基于肝形态生理学改善的营养证据，以及患者对膳食计划的依从性和在其文化背景下的适应性。因此，本综述的目的是探讨和比较管理 NAFLD 的最相关临床实践指南和营养方法的细微差别和细微差别，特别关注切实的结果和长期依从性。
