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Long-term treatment outcomes and safety of dupilumab as a therapy for bullous pemphigoid: A multicenter retrospective review.

作者信息

Learned Christine, Cohen Stephanie R, Cunningham Kaitlynne, Alsukait Sarah, Santiago Sueheidi, Lu Jun, Rothe Marti, Nichols Anna, Rosmarin David

机构信息

Department of Dermatology, Tufts Medical Center, Boston, Massachusetts.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.

出版信息

J Am Acad Dermatol. 2023 Aug;89(2):378-382. doi: 10.1016/j.jaad.2023.03.036. Epub 2023 Apr 26.

DOI:10.1016/j.jaad.2023.03.036
PMID:37115111
Abstract
摘要

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IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes.大疱性类天疱疮中的IgG自身抗体在角质形成细胞中诱导致病性的依赖MyD88的促炎反应。
Nat Commun. 2025 Aug 6;16(1):7254. doi: 10.1038/s41467-025-62495-2.
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Immuno-oncologyDupilumab for bullous pemphigoid related to immune checkpoint inhibitors: a retrospective case series.免疫肿瘤学 度普利尤单抗治疗与免疫检查点抑制剂相关的大疱性类天疱疮：一项回顾性病例系列研究。
Oncologist. 2025 Sep 1;30(9). doi: 10.1093/oncolo/oyaf208.
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Efficacy and safety of dupilumab in patients with moderate-to-severe bullous pemphigoid: a systematic review and meta-analysis.
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An Bras Dermatol. 2025 May-Jun;100(3):429-438. doi: 10.1016/j.abd.2024.08.008. Epub 2025 Mar 29.
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Bullous pemphigoid.大疱性类天疱疮
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J Clin Med. 2024 Aug 16;13(16):4844. doi: 10.3390/jcm13164844.
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Dermatology. 2024;240(5-6):694-701. doi: 10.1159/000540590. Epub 2024 Jul 29.
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Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.度普利尤单抗通过抑制多种细胞类型的活性，有效且快速地治疗大疱性类天疱疮。
Front Immunol. 2023 Jul 27;14:1194088. doi: 10.3389/fimmu.2023.1194088. eCollection 2023.