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[脆弱患者的起搏器感染]

[Pacemaker infection in fragile patients].

作者信息

Casorelli Ernesto, Pescatori Ilaria, Ruocco Gaetano, Bonnemeier Hendrik, Assadian Ojan, Bui Franco

机构信息

Department for cardiology and intensive care medicine, Valdichiana Hospital, Località Nottola, Montepulciano, Italien.

Helios Klinik Cuxhaven, Altenwalder Chaussee 10, 27474, Cuxhaven, Deutschland.

出版信息

Herzschrittmacherther Elektrophysiol. 2023 Jun;34(2):161-164. doi: 10.1007/s00399-023-00940-9. Epub 2023 Apr 28.

DOI:10.1007/s00399-023-00940-9
PMID:37115248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10229671/
Abstract

Complications associated with cardiac implantable electric devices (CIED) are manifold. They include lead dislocation, twiddler's syndrome, device malfunction, haematoma formation and infection. Infections can be divided into acute, subacute and late infections. Both the time of onset and the route of infection play a crucial role. The consequences of a CIED infection are devastating. The most modern treatment methods include the removal of all implanted implants. If complete removal is not followed in the event of infection, there is a high rate of infection recurrence. Open thoracic surgery to remove infected CIED hardware has been replaced by percutaneous lead extraction procedures. Lead extraction requires specialised equipment and expertise and may not be readily available or feasible for some patients. Each extraction procedure is associated with a small risk of potentially fatal complications (e.g. cardiac avulsion, vascular avulsion, haemothorax and cardiac tamponade). For these reasons, the performance of such procedures should be limited to centres with adequate equipment and experience. Successful salvage of CIED systems with in situ sterilisation of contaminated hardware has been reported. In our case, we report the successful salvage of an exposed generator in a frail patient treated more than 5 years after the last generator replacement.

摘要

与心脏植入式电子装置(CIED)相关的并发症多种多样。它们包括导线脱位、旋弄综合征、装置故障、血肿形成和感染。感染可分为急性、亚急性和晚期感染。感染的发生时间和途径都起着至关重要的作用。CIED感染的后果是毁灭性的。最现代的治疗方法包括移除所有植入物。如果在感染时未进行彻底移除,感染复发率很高。开胸手术移除感染的CIED硬件已被经皮导线拔除术所取代。导线拔除需要专门的设备和专业知识,对一些患者来说可能并不容易获得或可行。每次拔除手术都有发生潜在致命并发症(如心脏撕裂、血管撕裂、血胸和心脏压塞)的小风险。由于这些原因,此类手术应仅限于具备适当设备和经验的中心进行。已有报道成功挽救CIED系统并对受污染硬件进行原位消毒。在我们的病例中,我们报告了在最后一次更换发生器5年多后,对一名体弱患者暴露的发生器进行成功挽救的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573c/10229671/328afd154b86/399_2023_940_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573c/10229671/19c1c20fc8a9/399_2023_940_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573c/10229671/328afd154b86/399_2023_940_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573c/10229671/19c1c20fc8a9/399_2023_940_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573c/10229671/328afd154b86/399_2023_940_Fig2_HTML.jpg

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引用本文的文献

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BMC Cardiovasc Disord. 2024 Jul 23;24(1):380. doi: 10.1186/s12872-024-04038-z.
2
Factors of mortality in patients with cardiac implantable electronic device: 5-year experience.心脏植入式电子设备患者的死亡率因素:5 年经验。
Rev Assoc Med Bras (1992). 2024 May 3;70(4):e20230998. doi: 10.1590/1806-9282.20230998. eCollection 2024.
3
The European TauroPace™ Registry.欧洲TauroPace™注册研究。

本文引用的文献

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Use of a taurolidine containing antimicrobial wash to reduce cardiac implantable electronic device infection.使用含牛磺罗定的抗菌洗液可减少心脏植入式电子设备感染。
Europace. 2023 Oct 5;25(10). doi: 10.1093/europace/euad306.
2
Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine.使用牛磺罗定根除小儿患者的心室辅助装置导线感染
J Cardiovasc Dev Dis. 2022 Jan 10;9(1):18. doi: 10.3390/jcdd9010018.
3
European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections-endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).
Methods Protoc. 2023 Sep 15;6(5):86. doi: 10.3390/mps6050086.
欧洲心脏病学会(EHRA)关于如何预防、诊断和治疗心脏植入式电子设备感染的国际共识文件——得到了心律学会(HRS)、亚太心律学会(APHRS)、拉丁美洲心律学会(LAHRS)、心血管感染性疾病国际学会(ISCVID)和欧洲临床微生物学和传染病学会(ESCMID)的认可,该共识文件是与欧洲心胸外科学会(EACTS)合作制定的。
Europace. 2020 Apr 1;22(4):515-549. doi: 10.1093/europace/euz246.
4
Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association.心脏植入式电子设备感染的预防、诊断和管理指南的临床实践和实施:在欧洲心律协会主持下进行的全球调查结果。
Europace. 2019 Aug 1;21(8):1270-1279. doi: 10.1093/europace/euz137.
5
Attempted salvage of infected cardiovascular implantable electronic devices: Are there clinical factors that predict success?感染性心血管植入式电子设备的挽救尝试:是否存在预测成功的临床因素?
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High prevalence of asymptomatic bacterial colonization of rhythm management devices.节律管理设备无症状细菌定植的高发生率。
Europace. 2008 Sep;10(9):1067-72. doi: 10.1093/europace/eun191. Epub 2008 Jul 25.