Morita-Tanaka Satomi, Miyagawa-Hayashino Aya, Yamada Tadaaki, Matsui Yohei, Morimoto Kenji, Hiranuma Osamu, Masuzawa Naoko, Yoshimura Akihiro, Iwasaku Masahiro, Tokuda Shinsaku, Kaneko Yoshiko, Kim Young Hak, Konishi Eiichi, Takayama Koichi
Department of Respiratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Support Care Cancer. 2023 Apr 28;31(5):308. doi: 10.1007/s00520-023-07771-x.
Growth differentiation factor-15 (GDF-15) is one of the key cachexia-inducing factors. Clinical trials on therapies targeting GDF-15 for cancer and cancer cachexia are underway. While the role of circulating GDF-15 in cachexia has been clarified, the effects of GDF-15 expression within cancer cells remain to be fully elucidated. Hence, the objective of this study was to investigate the expression of GDF-15 in advanced lung cancer tissues and to understand its role in cachexia.
We retrospectively examined the expression level of full-length GDF-15 in advanced non-small cell lung cancer tissues and analyzed the relationship between the staining intensity and clinical data in 53 samples.
We found that 52.8% of the total samples were GDF-15 positive, and GDF-15 expression significantly correlated with improved C-reactive protein/albumin ratio (p = 0.008). It did not correlate with the existence of cancer cachexia and overall survival (p = 0.43).
Our findings show that GDF-15 expression significantly correlated with improved C-reactive protein/albumin ratio, but not the existence of cancer cachexia in advanced NSCLC patients.
生长分化因子15（GDF - 15）是诱导恶病质的关键因子之一。针对GDF - 15治疗癌症及癌症恶病质的临床试验正在进行。虽然循环GDF - 15在恶病质中的作用已得到阐明，但癌细胞内GDF - 15表达的影响仍有待充分阐明。因此，本研究的目的是调查GDF - 15在晚期肺癌组织中的表达，并了解其在恶病质中的作用。
我们回顾性检查了53例晚期非小细胞肺癌组织中全长GDF - 15的表达水平，并分析了染色强度与临床数据之间的关系。
我们发现，总样本中有52.8%的GDF - 15呈阳性，且GDF - 15表达与C反应蛋白/白蛋白比值的改善显著相关（p = 0.008）。它与癌症恶病质的存在及总生存期无关（p = 0.43）。
我们的研究结果表明，GDF - 15表达与C反应蛋白/白蛋白比值的改善显著相关，但与晚期非小细胞肺癌患者癌症恶病质的存在无关。
