James T N
J Am Coll Cardiol. 1986 Jul;8(1 Suppl A):12A-21A. doi: 10.1016/s0735-1097(86)80024-9.
A coronary chemoreceptor and its neighboring nerves and ganglia were studied by serial section from the hearts of 11 victims of sudden unexpected death. Either focal or extensive inflammatory destruction was present in the chemoreceptors of 10 of the 11 hearts, and similar abnormalities of local nerves and ganglia were present in all 11 hearts. Because an identical coronary chemoreceptor in the dog has previously been shown to be the site of origin of a powerful reflex with major influence on the electrical activity of the heart, the functional significance of the neural abnormalities found in these 11 human hearts may include important distortion of cardiac rhythm, conduction or repolarization. Future studies are needed to determine the prevalence of such lesions in the hearts of other victims of sudden death and among control subjects, as well as to determine the etiology of this special neuropathology of the heart.
通过对11例意外猝死患者心脏的连续切片，研究了冠状动脉化学感受器及其相邻的神经和神经节。11例心脏中有10例的化学感受器存在局灶性或广泛性炎症破坏，所有11例心脏的局部神经和神经节均存在类似异常。因为先前已证明犬的相同冠状动脉化学感受器是一种强大反射的起源部位，对心脏的电活动有重大影响，所以在这11例人类心脏中发现的神经异常的功能意义可能包括心律、传导或复极化的重要改变。需要进一步研究以确定此类病变在其他猝死患者心脏以及对照人群中的患病率，同时确定这种特殊心脏神经病理学的病因。
