Male O, Zazgornik J, Schmidt P, Kopsa H
Wien Klin Wochenschr. 1979 Mar 2;91(5):170-3.
53 renal transplant recipients aged 13 to 58 years were followed up regularly clinically, microbiologically and serologically over observation periods ranging from 6 to 82 months following transplantation with a view to diagnosing mycetic complications. The only (facultative) pathogenic species found was Candida albicans. This species was isolated in every single patient, but far-reaching differences were observed with regard to the degree of form of infection in the individual person. Mainly, cases showed only a transient growth of Candida to a greater or lesser extent on the mucous membranes of the orointestinal tract, but in few cases serious systemic forms like fungaemia and urinary tract infections were manifest. Comparing the mycological and clinical findings it was apparent that the degree of mycetic infection and attendant complications was closely correlated to the incidence and severity of several--at least primarily--non-mycetic complications postoperatively, such as disorders of transplant function, rejection reactions, diabetes and bacterial infections. A causal connexion, thus, probably exists between postoperative mycetic and non-mycetic complications and the presumable underlying pathological mechanism is discussed.
对53名年龄在13至58岁之间的肾移植受者进行了定期的临床、微生物学和血清学随访，观察期为移植后6至82个月，目的是诊断真菌并发症。发现的唯一（兼性）致病菌种是白色念珠菌。该菌种在每一位患者中均被分离出来，但在个体感染的形式和程度方面观察到了很大差异。主要情况是，病例仅显示念珠菌在口腔肠道黏膜上或多或少有短暂生长，但少数情况下会出现严重的全身性感染，如真菌血症和尿路感染。比较真菌学和临床检查结果发现，真菌感染的程度和随之而来的并发症与术后几种（至少主要是）非真菌性并发症的发生率和严重程度密切相关，如移植功能障碍、排斥反应、糖尿病和细菌感染。因此，术后真菌性和非真菌性并发症之间可能存在因果联系，并对可能的潜在病理机制进行了讨论。
