Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
BMJ Open. 2023 Apr 28;13(4):e069956. doi: 10.1136/bmjopen-2022-069956.
Patients with a mediastinal mass are at risk of pulmonary complications in the perioperative period. Preoperative spirometry tests are recommended in patients scheduled for thoracic surgery. Our objective is to investigate the association between preoperative spirometry results and the incidence of postoperative pulmonary complications in patients following mediastinal mass resection, which may determine the usefulness of spirometry tests in the prediction of the perioperative respiratory risk.
This protocol describes a retrospective cohort study of patients with mediastinal masses in Shanghai Pulmonary Hospital between 1 September 2021 and 1 September 2022, with a planned sample size of 660 patients. The primary aim of this study is to explore the association between preoperative spirometry results and the occurrence of postoperative pulmonary complications after mediastinal mass resection. Logistic regression analysis will be used to calculate the adjusted incidence rate difference and incidence rate ratios (with 95% CIs).
The study was approved by the ethics committee of Shanghai Pulmonary Hospital (K21-372Y). The results of the study will be submitted to a peer-reviewed biomedical journal for publication and presented at relevant conferences.
纵隔肿块患者在围手术期有发生肺部并发症的风险。建议对拟行胸部手术的患者进行术前肺功能检查。我们的目的是研究纵隔肿块切除术后患者术前肺功能检查结果与术后肺部并发症发生率之间的关系，这可能有助于确定肺功能检查在预测围手术期呼吸风险方面的作用。
本方案描述了一项 2021 年 9 月 1 日至 2022 年 9 月 1 日期间在上海肺科医院进行的纵隔肿块患者回顾性队列研究，计划样本量为 660 例。本研究的主要目的是探讨纵隔肿块切除术前肺功能检查结果与术后肺部并发症发生之间的关系。将使用逻辑回归分析计算调整后的发生率差异和发生率比（95%置信区间）。
该研究得到了上海肺科医院伦理委员会的批准（K21-372Y）。研究结果将提交给同行评议的生物医学期刊发表，并在相关会议上展示。
