Department of Dermatology, The Royal Children's Hospital, Melbourne, VIC, Australia.
Department of Dermatology, St Vincent's Hospital, Melbourne, VIC, Australia.
Clin Exp Dermatol. 2023 Sep 19;48(10):1091-1101. doi: 10.1093/ced/llad162.
Recent advances in atopic dermatitis (AD) present the condition as a heterogeneous disease of distinct endotypes across ethnic groups. AD in people with skin of colour may appear psoriasiform, lichenoid, scaly or papular, with a violaceous colour and there is a higher prevalence of post-inflammatory dyspigmentation compared with affected individuals of White ethnicity. These differences in clinical presentation may limit the use of AD assessment tools in people with skin of colour, leading to the potential for misdiagnosis and underestimation of severity, particularly in relation to assessment of erythema. Recent targeted therapies for AD have been studied in multiple ethnic groups; however, ethnicity-based subgroup analysis is often not performed. Further research is required to understand whether treatment responses or safety may differ among ethnic groups.
特应性皮炎（AD）的最新进展表明，这种疾病在不同种族群体中存在不同的表型。有色人种的 AD 可能表现为银屑病样、苔藓样、鳞屑样或丘疹样，呈紫红色，与白种人相比，炎症后色素沉着过度的发生率更高。这些临床表现的差异可能限制了 AD 评估工具在有色人种中的使用，导致潜在的误诊和严重程度低估，尤其是在评估红斑方面。近年来，针对 AD 的靶向治疗已在多个种族群体中进行了研究；然而，通常不进行基于种族的亚组分析。需要进一步研究以了解治疗反应或安全性是否在不同种族群体中存在差异。
