儿童青光眼的结局指标：一项随机对照试验的系统评价。
Outcome measures in childhood glaucoma: a systematic review of randomized controlled trials.
机构信息
Department of Ophthalmology and Visual Sciences, University of Alberta, 400, 10924, 107 Avenue, Edmonton, AB, T5H 0X5, Canada.
Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2023 Sep;261(9):2625-2639. doi: 10.1007/s00417-023-06061-w. Epub 2023 Apr 29.
PURPOSE
To synthesize the outcome measures used by randomized controlled trials (RCTs) for childhood glaucoma.
METHODS
MEDLINE, EMBASE, and Scopus were searched from inception to February 17, 2023. Randomized controlled trials and observational studies related to childhood glaucoma were included. Primary and secondary outcomes were extracted and the data was used to generate a literature review.
RESULTS
This review identified 42 unique reports pertaining to childhood glaucomas. Most of the studies originated from Egypt, India, and the USA. Intraocular pressure (IOP) outcomes were the most frequent outcomes studied, followed by clinical outcomes and safety outcomes. Clinical outcomes were the most common secondary outcomes studied, followed by IOP outcomes and safety outcomes.
CONCLUSIONS
This systematic review found heterogenous outcomes with IOP outcomes as the most studied primary outcome. As the remaining outcomes were not consistently utilized, this review highlights the need for a consensus on studies of pediatric glaucoma.
目的
综合儿童青光眼随机对照试验（RCT）使用的结局测量指标。
方法
从建库到 2023 年 2 月 17 日，检索 MEDLINE、EMBASE 和 Scopus。纳入与儿童青光眼相关的随机对照试验和观察性研究。提取主要结局和次要结局，并对数据进行文献综述。
结果
本综述共确定了 42 篇关于儿童青光眼的独特报告。大多数研究来自埃及、印度和美国。眼压（IOP）结局是研究最多的结局，其次是临床结局和安全性结局。临床结局是研究最多的次要结局，其次是 IOP 结局和安全性结局。
结论
本系统综述发现，以 IOP 结局为最常见主要结局的研究存在异质性结局。由于其余结局并未得到一致应用，因此本综述强调需要就儿科青光眼研究达成共识。
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