Lakshman K, Blackburn G L
J Clin Monit. 1986 Apr;2(2):114-20. doi: 10.1007/BF01637678.
Nutritional support is an important aspect of the multidisciplinary approach to critical care medicine. During stress, visceral protein turnover is increased. However, muscle and connective tissue proteolysis is obligatory if the stressful condition persists. Through nutritional support, peripheral protein breakdown is minimized and visceral protein synthesis maximized. A delivery system of 15% to 20% dietary protein, 30% fat, 50% to 55% carbohydrate, complemented by moderate amounts of vitamins and minerals, is considered best. Optimal nutritional care depends on objective assessment of the patient's nutritional status before and during nutritional support, particularly the nutritional status of the body cell mass and the energy required for maintenance and support of reparative processes. Indicators least disturbed by factors should be selected for assessment. Individual indicators vary in critical states. After resuscitation, excess body water may increase body weight; after surgery, stress may depress albumin levels. Biometric markers of nutritional status and measurements that adequately validate and evaluate response to nutritional support are discussed.
营养支持是危重病医学多学科治疗方法的一个重要方面。在应激状态下,内脏蛋白周转增加。然而,如果应激状态持续存在,肌肉和结缔组织的蛋白水解是不可避免的。通过营养支持,可将外周蛋白分解降至最低,并使内脏蛋白合成最大化。一种由15%至20%的膳食蛋白质、30%的脂肪、50%至55%的碳水化合物组成,并辅以适量维生素和矿物质的输送系统被认为是最佳的。最佳营养护理取决于对患者营养支持前后营养状况的客观评估,特别是体细胞群的营养状况以及维持和支持修复过程所需的能量。应选择受因素干扰最小的指标进行评估。在危急状态下,个体指标会有所不同。复苏后,体内多余水分可能会增加体重;手术后,应激可能会降低白蛋白水平。本文讨论了营养状况的生物计量标志物以及能够充分验证和评估对营养支持反应的测量方法。