关于 ZEB1-AS1 在人类疾病中的作用的综述。
A review on the role of ZEB1-AS1 in human disorders.
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Pathol Res Pract. 2023 May;245:154486. doi: 10.1016/j.prp.2023.154486. Epub 2023 Apr 26.
ZEB1 Antisense RNA 1 (ZEB1-AS1) is a type of RNA characterized as long non-coding RNA (lncRNA). This lncRNA has important regulatory roles on its related gene, Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In addition, role of ZEB1-AS1 has been approved in diverse malignancies such as colorectal cancer, breast cancer, glioma, hepatocellular carcinoma and gastric cancer. ZEB1-AS1 serves as a sponge for a number of microRNAs, namely miR-577, miR-335-5p, miR-101, miR-505-3p, miR-455-3p, miR-205, miR-23a, miR-365a-3p, miR-302b, miR-299-3p, miR-133a-3p, miR-200a, miR-200c, miR-342-3p, miR-214, miR-149-3p and miR-1224-5p. In addition to malignant conditions, ZEB1-AS1 has functional role in non-malignant conditions like diabetic nephropathy, diabetic lung, arthrosclerosis, Chlamydia trachomatis infection, pulmonary fibrosis and ischemic stroke. This review outlines different molecular mechanisms of ZEB1-AS1 in a variety of disorders and highlights its importance in their pathogenesis.
ZEB1 反义 RNA1（ZEB1-AS1）是一种长链非编码 RNA（lncRNA）。这种 lncRNA 对其相关基因——锌指 E 盒结合同源盒 1（ZEB1）具有重要的调节作用。此外，ZEB1-AS1 在多种恶性肿瘤中如结直肠癌、乳腺癌、神经胶质瘤、肝癌和胃癌中发挥作用已得到证实。ZEB1-AS1 作为多种 microRNA 的海绵，包括 miR-577、miR-335-5p、miR-101、miR-505-3p、miR-455-3p、miR-205、miR-23a、miR-365a-3p、miR-302b、miR-299-3p、miR-133a-3p、miR-200a、miR-200c、miR-342-3p、miR-214、miR-149-3p 和 miR-1224-5p。除了恶性疾病外，ZEB1-AS1 在非恶性疾病如糖尿病肾病、糖尿病肺、动脉硬化、沙眼衣原体感染、肺纤维化和缺血性中风中也具有功能作用。这篇综述概述了 ZEB1-AS1 在多种疾病中的不同分子机制，并强调了其在发病机制中的重要性。
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