Exerts Oncogenic Functions and Promotes Chemoresistance in Cisplatin-Resistant Cervical Cancer Cells.

Long noncoding RNAs (lncRNAs) are important regulators in various human diseases. The lncRNA is a tumor promoter in ovarian cancer, glioma, and lung cancer, but the specific effects of on cervical cancer (CC) chemoresistance remain unclear. Here, the level of HOXD-AS1 in nonmalignant and CC tissues as well as in CC cells and cisplatin-resistant CC cells was determined. qRT-PCR indicated that was overexpressed in CC tissues and cisplatin-resistant CC cells. Loss-of-function assays showed that downregulation of expression suppressed chemoresistance of cisplatin-resistant CC cells. targeted , and in gain-of-function assays could reverse cisplatin resistance of CC cells. in turn targeted zinc finger E-box homeobox 1 (). These results collectively show that HOXD-AS1 can act as a competing endogenous RNA to upregulate expression via . The effects of the axis on cisplatin resistance of cisplatin-resistant CC cells were supported by rescue assay results. In summary, enhanced chemoresistance of cisplatin-resistant CC cells by modulating axis expression.