Lear J L
J Nucl Med. 1986 Jun;27(6):788-94.
We compared the effects of symptom-limited upright and supine exercise on 201Tl distribution and kinetics in the heart and lungs of 100 consecutive patients. Our analysis was based on data obtained with a digital gamma camera in the 45 degrees left anterior oblique position at 5, 40, 240, and 275 min postadministration of [201Tl]chloride. We found significant differences in the results at the 5- and 40-min intervals; viz, higher cardiac and lower pulmonary thallium activity after upright exercise in 94 subjects at both intervals, and greater variability in total and regional cardiac thallium kinetics after supine exercise. With supine exercise, the relatively low initial cardiac activity, relatively high lung activity, and the greater variability in thallium kinetics combined to make interpretation of quantitative data and cardiac images difficult and less accurate with respect to detection of coronary artery disease. These observations have important implications for the interpreting physician when thallium stress tests are performed in the supine position.
我们比较了症状限制性直立运动和仰卧运动对100例连续患者心脏和肺部201Tl分布及动力学的影响。我们的分析基于在静脉注射氯化[201Tl]后5、40、240和275分钟，于45度左前斜位用数字γ相机获得的数据。我们发现在5分钟和40分钟时结果有显著差异；即在这两个时间点，94例受试者直立运动后心脏铊活性较高而肺部铊活性较低，且仰卧运动后心脏铊动力学的总量和区域变异性更大。对于仰卧运动，相对较低的初始心脏活性、相对较高的肺部活性以及铊动力学更大的变异性，共同导致在检测冠状动脉疾病方面定量数据和心脏图像的解读困难且准确性降低。当在仰卧位进行铊负荷试验时，这些观察结果对解读医师具有重要意义。
