从宁夏枸杞根皮中分离得到的 4 种新的非对映异构新木脂素糖苷及其α-葡萄糖苷酶抑制活性。
Four new diastereoisomeric neolignan glycosides from the root bark of Lycium chinense Miller. and their α-glucosidase inhibitory activity.
机构信息
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China.
出版信息
Fitoterapia. 2023 Jul;168:105520. doi: 10.1016/j.fitote.2023.105520. Epub 2023 Apr 28.
Four new diastereoisomeric neolignan glycosides (1-4) along with nine known lignan glycosides (5-13) were isolated from the root bark of Lycium chinense Mill. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy, ECD, Mo(OAc)-induced ECD spectra, enzymatic hydrolysis and acid hydrolysis. The isolated compounds were evaluated for their α-glucosidase inhibitory activity. Compounds 8 and 13 exhibited moderate inhibitory activities against α-glucosidase with IC values of 26.82 ± 2.71 and 43.14 ± 2.81 μg/mL.
从宁夏枸杞的根皮中分离得到了四个新的非对映异构新木脂素糖苷（1-4）和九个已知的木脂素糖苷（5-13）。基于 NMR 光谱、ECD、Mo(OAc)-诱导的 ECD 光谱、酶解和酸解，确定了它们的结构和绝对构型。对分离得到的化合物进行了α-葡萄糖苷酶抑制活性评价。化合物 8 和 13 对α-葡萄糖苷酶表现出中等抑制活性，IC 值分别为 26.82 ± 2.71 和 43.14 ± 2.81 μg/mL。
Zotero 插件