State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
J Agric Food Chem. 2012 Feb 1;60(4):964-72. doi: 10.1021/jf204660c. Epub 2012 Jan 24.
Rhodiola crenulata L. is an important species in genus Rhodiola widely used as a health food to reinforce immunity, improve memory and learning, scavenge active-oxygen species, and relieve altitude sickness. Eleven new lignans and a new benzonitrile compound, crenulatanoside A, were isolated from the roots of R. crenulata L. along with 25 known compounds, including 12 lignans. The structures of these compounds were elucidated by spectroscopic data and chemical evidence. Among them, compounds 1-4 and 5-7 were determined to be optical isomers of two 8-O-4' neolignan glycosides. Compounds 8-11 were aryl tetralin type lignans, and compounds 12 and 13 were dihydrobenzofuran neolignans. All of the isolated compounds were evaluated for their inhibitory activity against α-glucosidase. From the data obtained, compound 37 showed strong inhibitory activity against α-glucosidase with an IC(50) value of 96.8 μM.
秀丽红景天（Rhodiola crenulata L.）是红景天属的一种重要植物，被广泛用作保健品，以增强免疫力、改善记忆和学习能力、清除活性氧物种和缓解高原反应。从秀丽红景天（Rhodiola crenulata L.）的根部分离得到了 11 个新的木脂素和一个新的苯甲腈化合物，即 crenulatanoside A，以及 25 个已知化合物，包括 12 个木脂素。通过光谱数据和化学证据阐明了这些化合物的结构。其中，化合物 1-4 和 5-7 被确定为两种 8-O-4'新木脂素糖苷的对映异构体。化合物 8-11 为芳基四氢萘型木脂素，化合物 12 和 13 为二氢苯并呋喃新木脂素。对所有分离得到的化合物进行了α-葡萄糖苷酶抑制活性评价。结果表明，化合物 37 对α-葡萄糖苷酶具有较强的抑制活性，IC50 值为 96.8 μM。
