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来自枸杞根皮的具有强效抗高血脂活性的木脂酰胺类化合物。

Lignanamides with potent antihyperlipidemic activities from the root bark of Lycium chinense.

作者信息

Chen Hui, Li Yu-Jie, Sun Yan-Jun, Gong Jian-Hong, Du Kun, Zhang Yan-Li, Su Cheng-Fu, Han Qian-Qian, Zheng Xiao-Ke, Feng Wei-Sheng

机构信息

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; Collaborative Innovation Center for Respiratory Disease Diagnosis, Treatment and New Drug Research and Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China.

School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China.

出版信息

Fitoterapia. 2017 Oct;122:119-125. doi: 10.1016/j.fitote.2017.09.004. Epub 2017 Sep 8.

DOI:10.1016/j.fitote.2017.09.004
PMID:28890177
Abstract

Seven new lignanamides, lyciumamides D-J (1-4 and 9-11), together with nine known analogues (5-8 and 12-16), were isolated from the root bark of Lycium chinense. The structures of the isolated compounds were elucidated on the basis of NMR spectroscopic and HRESIMS data. All isolated compounds were evaluated for antihyperlipidemic activities in HepG2 cells. The primary structure-activity relationships were discussed.

摘要

从枸杞根皮中分离出7种新的木脂酰胺类化合物，即枸杞酰胺D-J（1-4和9-11），以及9种已知类似物（5-8和12-16）。根据核磁共振光谱和高分辨电喷雾电离质谱数据阐明了分离得到的化合物的结构。对所有分离得到的化合物在HepG2细胞中进行了抗高血脂活性评价，并讨论了初步的构效关系。

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