Department of Animal Pathology and Epidemiology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Arch Razi Inst. 2022 Oct 31;77(5):2007-2011. doi: 10.22092/ARI.2022.357062.1963. eCollection 2022 Oct.
A 13-years-old male vervet monkey that was kept in a primates breeding and research facility at Razi Vaccine and Serum Research Institute, Karaj, Iran (RVSRI) died suddenly. Massively scattered grayish-yellow mottling on both ventricles were the most significant gross necropsy findings. There was a gritty feeling on palpation and sectioning of the yellow areas. Microscopically, the lesions demonstrated scattered degeneration and necrosis of myocardial cells. Inside the affected areas, large calcium deposit plaques were detected using the Von kossa staining method. The development of myocardial calcification in the present case can be attributed to the dystrophic calcification following spontaneous myocardial necrosis or an undetected infection/inflammatory process. Persistent anxiety might trigger spontaneous biventricular necrosis in vervet monkeys. In conclusion, due to similarities between the clinical and histological presentation of the current case with sudden death syndrome associated with myocardial calcification in humans, it was suggested that vervet monkeys might be a relevant animal model for research on the pathophysiological processes of this complication.
一只 13 岁的雄性长尾猕猴突然死亡，该猕猴被饲养在伊朗拉齐疫苗和血清研究所（Razi Vaccine and Serum Research Institute）的灵长类动物繁殖和研究设施中。剖检最显著的发现是两个心室广泛散布的灰黄色斑驳。触诊和切开黄色区域时有粗糙感。镜下，病变显示心肌细胞散在变性和坏死。用 Von kossa 染色法在受影响的区域内检测到大量钙沉积斑块。目前这种心肌钙化的发生可归因于自发性心肌坏死或未检测到的感染/炎症过程后的营养不良性钙化。持续的焦虑可能会引发长尾猕猴的双侧心室自发性坏死。总之，由于本病例的临床和组织学表现与人类伴钙化的心肌猝亡综合征相似，因此建议长尾猕猴可能是研究这种并发症病理生理过程的相关动物模型。
