10年间人类免疫缺陷病毒感染者历史队列中心血管危险因素的患病率。
Prevalence of cardiovascular risk factors in a historical cohort of people living with human immunodeficiency virus during a 10-year period.
作者信息
García-Peña Ángel, Aldana Jairo, Botero Juan David, Vasquez Juan Manuel, León Miguel, Rodríguez-Lugo Diego, Villamil Lina, Barahona-Correa Julián E, Tamara Jose
机构信息
Department of Internal Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
Division of Cardiology, Hospital Universitario San Ignacio, Bogotá, Colombia.
出版信息
SAGE Open Med. 2023 Apr 24;11:20503121231166647. doi: 10.1177/20503121231166647. eCollection 2023.
OBJECTIVE
Data on the frequency of cardiovascular disease in people living with human immunodeficiency virus from low- and middle-income countries is scarce.
METHODS
We performed an observational study based on data from a historical cohort of people living with human immunodeficiency virus in Colombia during a 10-year follow-up to describe the prevalence of cardiovascular risk factors and their behavior according to CD4 count.
RESULTS
One thousand patients were initially included, out of which 390 had a 10-year follow-up. The mean age was 34 (standard deviation 10) years, and 90% were male. We observed an increase in the prevalence of dyslipidemia (29%-52%, < 0.001) and obesity (1.1%-3.5%, < 0.001). Major cardiovascular events occurred in less than 1% of patients. Patients with a CD4 count <200 cells/mm had a higher frequency of acute myocardial infarction and obesity.
CONCLUSION
Over time, people living with human immunodeficiency virus present with an increasing prevalence of cardiovascular risk factors, particularly those with a lower CD4 count.
目的
来自低收入和中等收入国家的人类免疫缺陷病毒感染者心血管疾病发生频率的数据匮乏。
方法
我们基于哥伦比亚一个人类免疫缺陷病毒感染者历史队列的数据进行了一项观察性研究，随访10年，以描述心血管危险因素的患病率及其根据CD4细胞计数的变化情况。
结果
最初纳入1000例患者，其中390例进行了10年随访。平均年龄为34（标准差10）岁，90%为男性。我们观察到血脂异常患病率（29% - 52%，<0.001）和肥胖患病率（1.1% - 3.5%，<0.001）有所增加。主要心血管事件发生在不到1%的患者中。CD4细胞计数<200个/mm的患者急性心肌梗死和肥胖的发生率更高。
结论
随着时间推移，人类免疫缺陷病毒感染者心血管危险因素的患病率不断上升，尤其是CD4细胞计数较低者。
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