Fives Kaila R, Chism Danielle A, Beetz Bailey, Elkins Isaac, Butala Madhura
School of Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
Pediatrics, Ascension St. Vincent's, Jacksonville, USA.
Cureus. 2023 Mar 29;15(3):e36860. doi: 10.7759/cureus.36860. eCollection 2023 Mar.
Hemolytic disease of the fetus and newborn (HDFN) is an immune-mediated condition caused by the production of maternal antibodies to fetal red blood cells. This condition most commonly arises due to Rh factor incompatibility. The case presented here displays an example of HDFN in which the mother and fetus's blood type was O+. Upon further investigation, it was determined that the mother is a producer of anti-Gonzales antibodies (anti-Go(a)). With no cases published in the 21st century, this antibody is a rare cause of HDFN. Anti-Go(a) is produced against the Go antigen, a low-frequency Rh antigen found predominantly in African and Puerto Rican populations. Bringing awareness to this rare cause of HDFN may accelerate diagnosis when the physician is faced with non-ABO and non-Rh isoimmunization in these ethnic groups.
胎儿和新生儿溶血病（HDFN）是一种免疫介导的病症，由母体产生针对胎儿红细胞的抗体所致。这种病症最常见的原因是Rh因子不相容。此处呈现的病例展示了一例HDFN，其中母亲和胎儿的血型均为O+。进一步调查发现，母亲是抗冈萨雷斯抗体（抗-Go(a)）的产生者。由于21世纪尚无相关病例报道，这种抗体是HDFN的罕见病因。抗-Go(a)是针对Go抗原产生的，Go抗原是一种低频Rh抗原，主要见于非洲和波多黎各人群。当医生面对这些种族群体中的非ABO和非Rh同种免疫时，提高对这种HDFN罕见病因的认识可能会加速诊断。
