Ganji Niloofar, Alganabi Mashriq, Yamoto Masaya, Chusilp Sinobol, Pierro Agostino, Li Bo
Division of General and Thoracic Surgery, Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Front Pediatr. 2023 Apr 12;11:1089229. doi: 10.3389/fped.2023.1089229. eCollection 2023.
Family-involved care in the neonatal intensive care unit (NICU) helps to alleviate neonatal anxiety and promotes breastmilk intake, body growth and neurological development, but its effect on reducing the incidence of neonatal sepsis is not known. We conducted a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate whether neonates receiving family care have a lower incidence of neonatal sepsis compared to neonates receiving standard NICU care.
MEDLINE, Embase, Web of Science, and CENTRAL were searched for RCTs that compared preterm neonates receiving family care vs. standard NICU care. From 126 articles that were identified and screened, 34 full-text articles were assessed for eligibility, and 5 RCTs were included. The primary outcome was the development of sepsis. The RevMan 5.4 software was used to conduct the Meta-analysis.
The metanalysis, based on 5 RCTs demonstrated that neonates receiving family-involved care had significantly lower incidence of sepsis (12.0% vs. 16.3%), increased body weight, and reduced length of hospital stay compared to those receiving standard NICU care.
This study suggests that family-involved care in NICU can (i) reduce the incidence of neonatal sepsis, (ii) improve growth, and (iii) reduce the length of hospital stay. This study highlights the need for evaluating whether family-involved care improves other neonatal outcomes.
新生儿重症监护病房（NICU）中实施的家庭参与式护理有助于减轻新生儿焦虑，促进母乳摄入、身体生长和神经发育，但其对降低新生儿败血症发病率的影响尚不清楚。我们对随机对照试验（RCT）进行了系统评价和荟萃分析，以评估接受家庭护理的新生儿与接受标准NICU护理的新生儿相比，败血症发病率是否更低。
检索MEDLINE、Embase、Web of Science和CENTRAL数据库，查找比较接受家庭护理与标准NICU护理的早产儿的RCT。从识别和筛选出的126篇文章中，评估了34篇全文文章的 eligibility，纳入了5项RCT。主要结局是败血症的发生。使用RevMan 5.4软件进行荟萃分析。
基于5项RCT的荟萃分析表明，与接受标准NICU护理的新生儿相比，接受家庭参与式护理的新生儿败血症发病率显著更低（12.0%对16.3%），体重增加，住院时间缩短。
本研究表明，NICU中的家庭参与式护理可以（i）降低新生儿败血症的发病率，（ii）促进生长，（iii）缩短住院时间。本研究强调需要评估家庭参与式护理是否能改善其他新生儿结局。
