Srivastava V K, Chauhan S S, Srivastava P K, Kumar V, Misra U K
J Toxicol Environ Health. 1986;18(3):459-69. doi: 10.1080/15287398609530885.
Polycyclic aromatic hydrocarbons (PAH) were extracted from coal fly ash collected from the electrostatic precipitator of a thermal power plant. The PAH extract was given intratracheally daily to pregnant rats (2 mg/100 g body weight) on d 18 and 19 of gestation. In addition on d 19 of gestation rats were also given [3H]benzo[a]pyrene intratracheally. Rats were sacrificed on d 20 of gestation, and the distribution of [3H]benzo[a]pyrene radioactivity and PAH of coal fly ash was studied in maternal lung, liver, and placenta, as well as in the liver and lung of the fetus. The radioactivity of intratracheally given benzo[a]pyrene was found in liver (68%), placenta (4%), fetal lung (1.9%), and fetal liver (1.4%) of maternal lung. Intratracheally administered PAH of coal fly ash were translocated to maternal liver and placenta, as well as to the liver and lung of the fetus. PAH of coal fly ash were also metabolized to several minor and major metabolites by maternal lung, liver, and placenta, as well as by the maternal fetal liver and lung. Some of the PAH metabolites in lung and liver were common; however, the major metabolite of liver, M-16, was different from the major metabolite M-16 of lung. The major PAH metabolite of placenta, M-5, and fetal liver, F-12, were common PAH metabolites. M-2 and M-6 of the placenta and F-5 and F-10 of the fetal lung were also common.
多环芳烃（PAH）从一家热电厂静电除尘器收集的粉煤灰中提取。在妊娠第18天和第19天，每天经气管给怀孕大鼠注入PAH提取物（2毫克/100克体重）。此外，在妊娠第19天，还经气管给大鼠注入[3H]苯并[a]芘。在妊娠第20天处死大鼠，研究[3H]苯并[a]芘放射性以及粉煤灰中的PAH在母体肺、肝和胎盘，以及胎儿肝和肺中的分布。发现经气管注入的苯并[a]芘放射性存在于母体肺的肝（68%）、胎盘（4%）、胎儿肺（1.9%）和胎儿肝（1.4%）中。经气管给予的粉煤灰PAH转移到母体肝和胎盘，以及胎儿的肝和肺。粉煤灰中的PAH也被母体肺、肝和胎盘，以及母体-胎儿肝和肺代谢为几种主要和次要代谢产物。肺和肝中的一些PAH代谢产物是相同的；然而，肝的主要代谢产物M-16与肺的主要代谢产物M-16不同。胎盘的主要PAH代谢产物M-5和胎儿肝的F-12是常见的PAH代谢产物。胎盘的M-2和M-6以及胎儿肺的F-5和F-10也是常见的。
