Kurebe M, Asaoka H, Hiramatsu Y, Suzuki T, Okada K
Jpn J Antibiot. 1986 Feb;39(2):463-76.
The effect of a new antitumor antibiotic on the fertility was studied using SD rats. (2"R)-4'-O-Tetrahydropyranyladriamycin (THP) was administered to each rat at 0.01, 0.03 or 0.1 mg/kg daily. Males were given the drug intravenously for 63 days prior to mating and during the mating period; females were given the drug intravenously from 14 days prior to mating until day 7 of pregnancy. All the pregnant rats were sacrificed on day 20 of pregnancy, followed by external, visceral and skeletal observations of their fetuses. Results were summarized as follows. THP, at 0.1 mg/kg, suppressed body weight gain in females during the late period of pregnancy but did not affect body weight gain in males. THP, at 0.1 mg/kg, increased the numbers of dead fetuses and of resorptions. It caused no external, visceral or skeletal anomalies at any dose levels. The results suggest that, in rats, the maximum "no effect" dose of THP is 0.03 mg/kg/day intravenously regarding fertility and fetal development.
使用SD大鼠研究了一种新型抗肿瘤抗生素对生育能力的影响。每天以0.01、0.03或0.1mg/kg的剂量给每只大鼠静脉注射(2"R)-4'-O-四氢吡喃基阿霉素（THP）。雄性大鼠在交配前63天及交配期间静脉注射该药物；雌性大鼠在交配前14天至怀孕第7天静脉注射该药物。所有怀孕大鼠在怀孕第20天处死，随后对其胎儿进行外观、内脏和骨骼观察。结果总结如下。0.1mg/kg的THP在妊娠后期抑制了雌性大鼠的体重增加，但对雄性大鼠的体重增加没有影响。0.1mg/kg的THP增加了死胎和吸收胎的数量。在任何剂量水平下，它都没有引起外观、内脏或骨骼异常。结果表明，在大鼠中，就生育能力和胎儿发育而言，THP静脉注射的最大“无影响”剂量为0.03mg/kg/天。
