Kurebe M, Asaoka H, Hata T, Watanabe T, Hirota C
Jpn J Antibiot. 1984 Jun;37(6):1176-85.
A fertility study of MT-141 was performed in SD rats with the intramuscular (i.m.) injections at the dose levels of 400, 800 and 1,600 mg/kg/day. The male rats were injected with MT-141 for 63 days before mating and during the mating period, while the female rats were injected with MT-141 from the 14th day before mating up to the day 7 of gestation. All pregnant rats were sacrificed on day 20 of gestation followed by external, visceral and skeletal observations of their fetuses. The results are summarized as follows. The suppression of body weight gain was observed in males given above 800 mg/kg/day i.m. and in females of all treated groups during early period of gestation. However, no significant differences were found between treated groups and the control with regard to copulation rate and conception rate. Though no defects were observed for visceral and skeletal specimens in the fetuses of treated groups, MT-141 produced a delayed ossification of forelimbs in the fetuses at the doses above 800 mg/kg/day and of sternebrae at the dose of 1,600 mg/kg/day. It is concluded from the above-mentioned results that the maximal "no 'effective" dose of MT-141 on the fertility is above 1,600 mg/kg/day i.m. in parental rats and less than 800 mg/kg/day i.m. for the fetuses.
在SD大鼠中进行了MT - 141的生殖力研究，通过肌肉注射给予剂量水平为400、800和1600mg/kg/天。雄性大鼠在交配前和交配期间注射MT - 141共63天，而雌性大鼠在交配前第14天至妊娠期第7天注射MT - 141。所有怀孕大鼠在妊娠第20天处死，随后对其胎儿进行外部、内脏和骨骼观察。结果总结如下。肌肉注射剂量高于800mg/kg/天的雄性大鼠以及所有处理组的雌性大鼠在妊娠早期体重增加受到抑制。然而，在交配率和受孕率方面，处理组与对照组之间未发现显著差异。尽管在处理组胎儿的内脏和骨骼标本中未观察到缺陷，但MT - 141在剂量高于800mg/kg/天时会导致胎儿前肢骨化延迟，在剂量为1600mg/kg/天时会导致胸骨骨化延迟。从上述结果得出结论，MT - 141对亲代大鼠生殖力的最大“无效应”剂量肌肉注射高于1600mg/kg/天，对胎儿则低于800mg/kg/天。
