Shi Mili, Liu Xiaobo, Song Qiuyan, Shi Yijie, Tai Qirui
Department of Pharmacy, People's Hospital of Yuxi City, Yuxi, Yunnan 653100, China.
College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China.
Open Life Sci. 2023 Apr 28;18(1):20220589. doi: 10.1515/biol-2022-0589. eCollection 2023.
The aim of this study was to systematically evaluate the correlation between the rs231775 locus polymorphism in the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene and genetic susceptibility to Graves' disease (GD) in children. Some studies found that the CTLA-4 gene polymorphism was associated with GD in children. The data up to February 2022 were retrieved from the databases. Stata 15.0 software was used for meta-analysis. A total of seven studies were included in our research. The results of the meta-analysis showed that the rs231775 locus polymorphism in the CTLA-4 gene in general and Asian populations was correlated with children's susceptibility to GD (A vs G: OR = 0.75, 95% CI (0.660-0.86); GG vs AA: OR = 1.34, 95% CI (1.04-1.73); AG vs AA: OR = 1.32, 95% CI (1.02-1.10); AG + GG vs AA: OR = 3.81, 95% CI (2.17-6.70); GG vs AA + AG: OR 1.23, 95% CI (1.05-1.45)). In summary, the rs231775 locus polymorphism in the CLTA-4 gene may be a risk factor for GD in Asian children. The G allele may be a susceptibility factor, while the allele A may be a protective factor against GD in Asian children. In the future, more large-scale studies may be needed to verify our results.
本研究旨在系统评价细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因rs231775位点多态性与儿童Graves病（GD）遗传易感性之间的相关性。一些研究发现CTLA-4基因多态性与儿童GD有关。检索截至2022年2月的数据库数据。采用Stata 15.0软件进行荟萃分析。本研究共纳入7项研究。荟萃分析结果显示，CTLA-4基因rs231775位点多态性在总体人群和亚洲人群中与儿童GD易感性相关（A与G：OR = 0.75，95%CI（0.660 - 0.86）；GG与AA：OR = 1.34，95%CI（1.04 - 1.73）；AG与AA：OR = 1.32，95%CI（1.02 - 1.10）；AG + GG与AA：OR = 3.81，95%CI（2.17 - 6.70）；GG与AA + AG：OR = 1.23，95%CI（1.05 - 1.45））。综上所述，CLTA-4基因rs231775位点多态性可能是亚洲儿童GD的一个危险因素。G等位基因可能是一个易感因素，而A等位基因可能是亚洲儿童GD的一个保护因素。未来可能需要更多大规模研究来验证我们的结果。
