Tu Yaqin, Fan Guorun, Dai Yu, Zeng Tianshu, Xiao Fei, Chen Lulu, Kong Wen
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Oncotarget. 2017 Nov 27;8(66):110614-110624. doi: 10.18632/oncotarget.22702. eCollection 2017 Dec 15.
We conducted a case/control study to assess the impact of SNP rs3087243 and rs231775 within the gene, on the susceptibility to Graves' disease (GD) in a Chinese Han dataset (271 cases and 298 controls). The frequency of G allele for rs3087243 and rs231775 was observed to be significantly higher in subjects with GD than in control subjects ( = 0.005 and = 0.000, respectively). After logistic regression analysis, a significant association was detected between SNP rs3087243 and GD in the additive and recessive models. Similarly, association for the SNP rs231775 could also be detected in the additive model, dominant model and recessive model. A meta-analysis, including 27 published datasets along with the current dataset, was performed to further confirm the association. Consistent with our case/control results, rs3087243 and rs231775 showed a significant association with GD in all genetic models. Of note, ethnic stratification revealed that these two SNPs were associated with susceptibility to GD in populations of both Asian and European descent. In conclusion, our data support that the rs3087243 and rs231775 polymorphisms within the gene confer genetic susceptibility to GD.
我们进行了一项病例/对照研究，以评估该基因内的单核苷酸多态性（SNP）rs3087243和rs231775对中国汉族人群（271例病例和298例对照）Graves病（GD）易感性的影响。观察到rs3087243和rs231775的G等位基因频率在GD患者中显著高于对照受试者（分别为 = 0.005和 = 0.000）。经过逻辑回归分析，在加性和隐性模型中检测到SNP rs3087243与GD之间存在显著关联。同样，在加性模型、显性模型和隐性模型中也可检测到SNP rs231775的关联。进行了一项荟萃分析，纳入了27个已发表的数据集以及当前数据集，以进一步证实这种关联。与我们的病例/对照结果一致，rs3087243和rs231775在所有遗传模型中均显示与GD存在显著关联。值得注意的是，种族分层显示这两个SNP与亚洲和欧洲血统人群的GD易感性相关。总之，我们的数据支持该基因内的rs3087243和rs231775多态性赋予了GD遗传易感性。
