Xu Changhuo, Shen Hanchen, Liu Tzu-Ming, Kwok Ryan T K, Lam Jacky W Y, Tang Ben Zhong
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China.
iScience. 2023 Apr 8;26(5):106568. doi: 10.1016/j.isci.2023.106568. eCollection 2023 May 19.
In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates.
19世纪后期，科学家们开始研究发色团在溶液态和聚集态之间的光物理差异，这促成了对聚集导致猝灭和聚集诱导发光（AIE）等典型过程的认识。特别是，AIE现象的概念性发现催生了基于其独特的分子内运动受限工作原理的、在聚集态具有高发光性的发光材料的创新。由于AIE发光体已被实际制备成用于生物成像的AIE点，尽管这在技术上具有挑战性，但仍需要进一步提高其亮度。在这篇综述中，我们概述了高发射性AIE点的策略性分子工程的最新进展，包括纳米级结晶和基质辅助刚性化。我们希望这一及时的总结能够加深对AIE点高发射根源的理解，并为功能性聚集体的合理设计提供灵感。
