Morimoto I, Ninomiya H, Komatsu K, Satho M
Jpn J Med. 1986 Feb;25(1):59-62. doi: 10.2169/internalmedicine1962.25.59.
A 22-year-old female with Wilson's disease became pregnant and subsequently delivered a normal infant. At the age of 17 the patient presented evidence of liver cirrhosis and was diagnosed as having Wilson's disease. A regimen of d-penicillamine was started at this time and continued, although irregularly for the 10 months prior to her 9th week of pregnancy. At the 14th week of pregnancy she was started on 500 mg of D-penicillamine a day. She was stable during the remainder of her pregnancy and after delivery. Fetal development was normal and a normal infant was delivered at 35 weeks. It is suggested that pregnancy is not contraindicated in well treated Wilson's disease, and that a regimen of D-penicillamine during pregnancy can control the illness without harming the fetus.
一名患有威尔逊氏病的22岁女性怀孕，随后产下一名正常婴儿。患者17岁时出现肝硬化迹象，被诊断为威尔逊氏病。此时开始使用青霉胺治疗方案，并持续进行，尽管在怀孕第9周前的10个月里用药不规律。怀孕第14周时，她开始每天服用500毫克青霉胺。在怀孕剩余时间和分娩后她的病情稳定。胎儿发育正常，35周时产下一名正常婴儿。研究表明，病情得到良好治疗的威尔逊氏病患者怀孕并非禁忌，孕期使用青霉胺治疗方案可控制病情且不伤害胎儿。
