Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Neuropsychol Rehabil. 2024 May;34(4):469-484. doi: 10.1080/09602011.2023.2203403. Epub 2023 Apr 26.
This study aims to design and pilot an empirically based mobile application () to increase daily activity in persons with apathy and ADRD and test its feasibility and preliminary efficacy. was developed to address impairments in goal-directed behaviour, including difficulty with initiation, planning, and motivation that contribute to apathy. Participants included patients with apathy and MCI, mild bvFTD, or mild AD and their caregivers. In Phase I, 6 patient-caregiver dyads participated in 1-week pilot testing and focus groups. In Phase II, 24 dyads completed 4 weeks of at-home use. Baseline and follow-up visits included assessments of app usability, goal attainment, global cognition and functioning, apathy, and psychological symptoms. App use did not differ across diagnostic groups and was not associated with age, sex, education, global functioning or neuropsychiatric symptoms. Patients and care-partners reported high levels of satisfaction and usability, and care-partner usability rating predicted app use. At follow-up, participants showed significant improvement in goal achievement for all goal types combined. Participant goal-directed behaviour increased after 4 weeks of use. Patients and caregivers reported good usability and user satisfaction. Our findings support the feasibility and efficacy of mobile-health applications to increase goal-directed behaviour in ADRD.
本研究旨在设计并试点一个基于经验的移动应用程序(),以增加冷漠和 AD 的患者的日常活动,并测试其可行性和初步疗效。 是为了解决目标导向行为障碍而设计的,包括启动、计划和动机方面的困难,这些都导致了冷漠。参与者包括有冷漠和 MCI、轻度 bvFTD 或轻度 AD 的患者及其护理人员。在第一阶段,6 个患者-护理人员二人组参与了为期一周的试点测试和焦点小组。在第二阶段,24 对二人组完成了 4 周的家庭 使用。基线和随访包括评估应用程序的可用性、目标实现、整体认知和功能、冷漠和心理症状。应用程序的使用在不同的诊断组之间没有差异,也与年龄、性别、教育、整体功能或神经精神症状无关。患者和护理人员报告了高度的满意度和可用性,并且护理人员的可用性评分预测了应用程序的使用。在随访时,所有目标类型的目标实现都有显著改善。在 使用 4 周后,参与者的目标导向行为增加。患者和护理人员报告了良好的可用性和用户满意度。我们的研究结果支持移动健康应用程序在增加 AD 患者的目标导向行为方面的可行性和疗效。