Kamata K, Sugimoto A, Kameyama T
Jpn J Pharmacol. 1986 Mar;40(3):472-7. doi: 10.1254/jjp.40.472.
Effect of microinjection of apomorphine into the substantia nigra zona reticulata (SNR) on the dopamine (DA) release in the ipsilateral striatum was examined in the present study. To measure the DA release, we determined DA and/or DOPAC levels in the striatum by using in vivo voltammetry. The microinjection of apomorphine (10 micrograms/2 microliters) into the SNR produced a rapid and prolonged increase in the DA and/or DOPAC peak in the ipsilateral striatum. These results suggest that release of DA from dendrites of DA cells normally plays a physiological role in the SNR neurons.
本研究检测了向黑质网状部（SNR）微量注射阿扑吗啡对同侧纹状体中多巴胺（DA）释放的影响。为了测量DA释放，我们采用活体伏安法测定纹状体中DA和/或3,4-二羟基苯乙酸（DOPAC）的水平。向SNR微量注射阿扑吗啡（10微克/2微升）可使同侧纹状体中DA和/或DOPAC峰值迅速且持续升高。这些结果表明，DA细胞树突释放的DA通常在SNR神经元中发挥生理作用。
