Kamata K, Sugimoto A, Kameyama T
Brain Res. 1986 Aug 13;380(1):1-6. doi: 10.1016/0006-8993(86)91422-8.
To investigate the influence of the striatonigral gamma-aminobutyric acid (GABA) system on the nigrostriatal dopamine (DA) system, the release of DA and/or 3,4-dihydroxyphenylacetic acid in the striatum ipsilateral to the injection side was examined by in vivo voltammetry following microinjection of GABA into the substantia nigra zona reticulata (SNR). The microinjection of GABA (100-300 micrograms/2 microliters) into the SNR produced a dose-dependent increase in the electrochemical signals recorded from the caudate nucleus ipsilateral to the injection side. Following chronic treatment with haloperidol, microinjection of GABA into the SNR produced only a slight (non-significant) increase in the electrochemical signals recorded from the caudate nucleus ipsilateral to the injection side. These results provide additional evidence to support the concept that DA cells in the substantia nigra zona compacta are regulated by the SNR non-DA neurons in an inhibitory manner. It appears, furthermore, that chronic treatment with haloperidol reduces the release of DA in the striatum ipsilateral to the injection side and that this effect may be due to a gradual development of depolarization block of DA cells by chronic administration of haloperidol.
为研究纹状体黑质γ-氨基丁酸（GABA）系统对黑质纹状体多巴胺（DA）系统的影响，在向黑质网状部（SNR）微量注射GABA后，通过活体伏安法检测注射侧同侧纹状体中DA和/或3,4-二羟基苯乙酸的释放。向SNR微量注射GABA（100 - 300微克/2微升）可使注射侧同侧尾状核记录到的电化学信号呈剂量依赖性增加。用氟哌啶醇长期治疗后，向SNR微量注射GABA仅使注射侧同侧尾状核记录到的电化学信号有轻微（无统计学意义）增加。这些结果为支持黑质致密部的DA细胞受SNR非DA神经元以抑制方式调节这一概念提供了额外证据。此外，似乎长期用氟哌啶醇治疗会减少注射侧同侧纹状体中DA的释放，且这种效应可能是由于长期给予氟哌啶醇使DA细胞逐渐发生去极化阻滞所致。
