Rodionov A P, Berdiaev S Iu, Shestakova N V, Darinskiĭ N V, Kaverina N V
Kardiologiia. 1986 Apr;26(4):45-8.
Pharmacokinetics and pharmacodynamics of ethacizin were studied in a model of rhythm adoption by the heart, with the drug administered intravenously to anesthetized cats. A relation was demonstrated between blood ethacizin pattern and the drug's biphasic effect on the adoption of stimulation-imposed pace by the heart and ventricular fibrillation threshold. The estimated correlation coefficients, reflecting the relationship between the development of ethacizin anti-arrhythmic and antifibrillation effects and variation of its plasma levels between 10 and 120 min after the administration, were rather high (-0.85 and +0.93, respectively). Ethacizin shows anti-arrhythmic and antifibrillation activity when its plasma levels are between 2400 and 200 ng/ml.
在心脏节律调整模型中研究了乙胺碘呋酮的药代动力学和药效学，将该药物静脉注射给麻醉的猫。结果表明，血液中乙胺碘呋酮的变化模式与该药物对心脏接受刺激起搏和心室颤动阈值的双相效应之间存在关联。反映乙胺碘呋酮抗心律失常和抗纤颤作用的发展与其给药后10至120分钟血浆水平变化之间关系的估计相关系数相当高（分别为-0.85和+0.93）。当乙胺碘呋酮的血浆水平在2400至200 ng/ml之间时，它表现出抗心律失常和抗纤颤活性。
