Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-Ro, 173, Beon-Gil, Bundang-Gu, Seongnam, 13620, South Korea.
Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
J Anesth. 2023 Aug;37(4):522-531. doi: 10.1007/s00540-023-03197-1. Epub 2023 May 2.
This study aimed to investigate the association of modifiable lifestyle factors with long-term survival outcomes in patients with chronic non-cancer pain (CNCP) in South Korea.
This population-based cohort study used data from the National Health Insurance Service database in South Korea. We considered three lifestyle factors from the standard health examination (smoking status, alcohol consumption, and physical activity).
A total of 1,298,314 patients with CNCP were analyzed; moreover, the 5-year all-cause mortality rate was 3.3% (42,875 patients). In the multivariable Cox regression model, in the previous-smoker and current-smoker groups, it was 5% (hazard ratio [HR]:1.05, 95% confidence interval [CI]:1.02-1.08; P = 0.003) and 65% (HR: 1.65, 95% CI: 1.60-1.69; P < 0.001) higher, respectively, than that in the never-smoker group. The 5-year all-cause mortality was 19% (HR: 1.19, 95% CI: 1.14-1.24; P < 0.001) higher in the heavy-alcohol-consumption group than in the non-alcohol-consumption group. Compared with those without mild physical activity, patients who engaged in mild physical activity for 1-3 (HR: 0.89, 95% CI: 0.87-0.92; P < 0.001), 4-5 (HR: 0.88, 95% CI: 0.86-0.91; P < 0.001), and 6-7 (HR: 0.90, 95% CI: 0.88-0.93; P < 0.001) days per week exhibited a significantly decreased 5-year all-cause mortality. The association between moderate/intensive physical activity and 5-year all-cause mortality yielded similar results.
Lifestyle factors, including previous/current smoking, heavy alcohol consumption, and physical activity, were associated with a higher 5-year all-cause mortality risk among patients with CNCP in South Korea.
本研究旨在探讨可改变的生活方式因素与韩国慢性非癌性疼痛（CNCP）患者长期生存结局的关系。
本基于人群的队列研究使用了韩国国家健康保险服务数据库的数据。我们考虑了标准健康检查中的三种生活方式因素（吸烟状况、饮酒和身体活动）。
共分析了 1298314 例 CNCP 患者；此外，5 年全因死亡率为 3.3%（42875 例）。在多变量 Cox 回归模型中，与从不吸烟者相比，前吸烟者和现吸烟者的 5 年全因死亡率分别高出 5%（风险比 [HR]：1.05，95%置信区间 [CI]：1.02-1.08；P=0.003）和 65%（HR：1.65，95% CI：1.60-1.69；P<0.001）。与非饮酒组相比，重度饮酒组的 5 年全因死亡率高出 19%（HR：1.19，95% CI：1.14-1.24；P<0.001）。与没有轻度身体活动的患者相比，进行轻度身体活动 1-3（HR：0.89，95% CI：0.87-0.92；P<0.001）、4-5（HR：0.88，95% CI：0.86-0.91；P<0.001）和 6-7（HR：0.90，95% CI：0.88-0.93；P<0.001）天/周的患者 5 年全因死亡率显著降低。中度/剧烈体力活动与 5 年全因死亡率之间的关系得出了类似的结果。
包括既往/当前吸烟、大量饮酒和身体活动在内的生活方式因素与韩国 CNCP 患者较高的 5 年全因死亡率风险相关。
