Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China.
Department of Physical Education, Central South University, Changsha 410083, China.
Int J Environ Res Public Health. 2022 Jun 3;19(11):6849. doi: 10.3390/ijerph19116849.
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and approximately 50% of PD patients suffer from depression. We aim to determine the effects of physical activity on depression in PD patients and to provide scientific evidence-based exercise prescriptions for PD patients. A systematic review was conducted by searching PubMed, Embase, Cochrane Library, and PsycInfo until February 2022 for randomized controlled trial (RCT) studies published in English. The primary outcome was a score on a depression scale. A total of 14 RCTs involving 516 patients with PD were included in this study. The results of the meta-analysis showed that physical activity had a moderate and significant improvement in depression in PD patients (SMD = −0.60; 95% CI = −0.79 to −0.41; p < 0.00001). Subgroup analysis indicated that resistance exercise for 60−90 min more than 4 times per week for up to 12 weeks had a significant effect on PD patients who have had the disease for more than 5 years. Meta-regression showed that intervention type, intervention time, intervention frequency, intervention period, age, and disease duration were not sources of heterogeneity. Physical activity may reduce depression in PD patients. However, other larger sample sizes and high-quality studies are needed to validate these effects in the future.
帕金森病（PD）是全球第二常见的神经退行性疾病，约 50%的 PD 患者患有抑郁症。我们旨在确定身体活动对 PD 患者抑郁的影响，并为 PD 患者提供基于科学证据的运动处方。我们对截至 2022 年 2 月在 PubMed、Embase、Cochrane Library 和 PsycInfo 上发表的英文随机对照试验（RCT）进行了系统评价。主要结局是抑郁量表上的评分。这项研究共纳入了 14 项 RCT，涉及 516 名 PD 患者。荟萃分析结果表明，身体活动对 PD 患者的抑郁有中度且显著的改善（SMD = －0.60；95% CI = －0.79 至－0.41；p < 0.00001）。亚组分析表明，每周进行 4 次以上、每次持续 60-90 分钟的抗阻运动，持续 12 周，对患病超过 5 年的 PD 患者有显著效果。Meta 回归显示，干预类型、干预时间、干预频率、干预持续时间、年龄和疾病持续时间不是异质性的来源。身体活动可能会降低 PD 患者的抑郁程度。然而，未来需要更大的样本量和高质量的研究来验证这些效果。
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