Liu Tao, Zuo Ronghua, Song Jia, Wang Jia, Zhu Zhijian, Sun Lifang, Wang Shasha, Li Baoyin, Pan Yesheng, Wang Bing
Department of Cardiology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, 201500, People's Republic of China.
Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
J Inflamm Res. 2023 Apr 26;16:1825-1836. doi: 10.2147/JIR.S404668. eCollection 2023.
The association between serum uric acid (sUA) and incident abdominal aortic calcification (AAC), and severe abdominal aortic calcification (SAAC) in the general population of the United States (US) is unclear. Therefore, this research aimed to investigate the association between sUA and the risk of AAC and SAAC.
Individuals from National Health and Nutrition Examination Survey (NHANES) database were analyzed cross-sectionally between 2013 and 2014. The restricted cubic spline (RCS), multivariable logistic regression model and subgroup analysis were utilized to evaluate the correlation between sUA and incident AAC, and SAAC. In addition, generalized additive models with smooth functions were employed to survey the relationship between sUA and the degree of AAC.
This study included 3016 individuals from the NHANES database. According to the RCS plot, sUA levels were associated with the risk of AAC/SAAC in a U-shaped pattern in the US population. The degree of calcification decreased at first and then increased with the increase in the sUA level.
Close monitoring and adequate control of sUA levels in the US general population may reduce the risk of AAC and SAAC.
血清尿酸（sUA）与美国普通人群腹主动脉钙化（AAC）及严重腹主动脉钙化（SAAC）发病之间的关联尚不清楚。因此，本研究旨在探究sUA与AAC和SAAC风险之间的关联。
对2013年至2014年期间美国国家健康与营养检查调查（NHANES）数据库中的个体进行横断面分析。采用受限立方样条（RCS）、多变量逻辑回归模型和亚组分析来评估sUA与AAC及SAAC发病之间的相关性。此外，运用带有平滑函数的广义相加模型来研究sUA与AAC程度之间的关系。
本研究纳入了NHANES数据库中的3016名个体。根据RCS图，在美国人群中，sUA水平与AAC/SAAC风险呈U型关联。钙化程度起初下降，随后随着sUA水平的升高而增加。
对美国普通人群密切监测并适当控制sUA水平可能会降低AAC和SAAC的风险。
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