奥利司他漱口液：一种使用舌头传递抗肥胖药物的方法，在一项双盲随机交叉先导试验中。
Orlistat mouth rinse: Using the tongue to deliver antiobesity medication in a double-blind randomized crossover pilot trial.
机构信息
Department of Physiology, LSU Health-NO, New Orleans, Louisiana, USA.
Joint Diabetes, Endocrinology & Metabolism Program, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
出版信息
Diabetes Obes Metab. 2023 Aug;25(8):2236-2242. doi: 10.1111/dom.15101. Epub 2023 May 3.
AIM
To investigate the effects of an orlistat mouth rinse on the intake of a high-fat meal.
METHODS
A double-blind, balanced order, crossover study was conducted in participants (n = 10, body mass index 25-30 kg/m ) assigned to receive placebo or orlistat (24 mg/mL) prior to a high-fat meal. Participants were divided into low- or high-fat consumers based on calories consumed from fat following placebo administration.
RESULTS
The orlistat mouth rinse decreased total and fat calories consumed during the high-fat meal in high-fat consumers, and did not alter calories consumed in low-fat consumers (P < 0.05).
CONCLUSIONS
Orlistat decreases long-chain fatty acid (LCFA) absorption by inhibiting lipases that breakdown triglycerides. Orlistat mouth rinse decreased fat intake in high-fat consumers, suggesting that orlistat inhibited the detection of LCFAs from the high-fat test meal. Lingual delivery of orlistat is predicted to eliminate the risk of oil incontinence and promote weight loss in individuals who prefer fat.
目的
研究奥利司他漱口液对高脂餐摄入的影响。
方法
采用双盲、平衡序、交叉研究，将参与者（n=10，体重指数 25-30kg/m）分为接受安慰剂或奥利司他（24mg/mL）漱口液组，在高脂餐前使用。根据使用安慰剂后脂肪热量的摄入情况，将参与者分为低脂肪或高脂肪消费者。
结果
在高脂肪消费者中，奥利司他漱口液减少了高脂餐期间总热量和脂肪热量的摄入，而在低脂肪消费者中没有改变热量的摄入（P<0.05）。
结论
奥利司他通过抑制分解甘油三酯的脂肪酶来减少长链脂肪酸（LCFA）的吸收。奥利司他漱口液减少了高脂肪消费者的脂肪摄入，这表明奥利司他抑制了对高脂测试餐中 LCFA 的检测。预测奥利司他的舌部给药可以消除油性便失禁的风险，并促进喜欢脂肪的个体的体重减轻。
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