Oikarinen J, Korhonen L K
Acta Orthop Scand. 1979 Feb;50(1):21-6. doi: 10.3109/17453677909024085.
Experimental fibular defects in 16 rats were filled with an acid decalcified homogenous bone matrix (bone inductive material). Autogenous bone grafts in corresponding defects in the other legs of the same rats served as controls. After 3 months, 11 of the 16 defects filled with bone inductive material healed with bony union, but only 4 of the 16 defects treated with autogenous bone grafts had healed. The results suggest that bone inductive material can repair bone defects are too large to be healed by autogenous bone grafts.
在16只大鼠身上制造实验性腓骨缺损，并用酸脱钙的均质骨基质（骨诱导材料）填充。同一只大鼠另一条腿相应缺损处的自体骨移植作为对照。3个月后，16处填充骨诱导材料的缺损中有11处实现了骨愈合，但16处接受自体骨移植治疗的缺损中只有4处愈合。结果表明，骨诱导材料能够修复自体骨移植无法愈合的过大骨缺损。
