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[腮腺浆细胞瘤]

[Plasmacytoma of the parotid gland].

作者信息

Ebbers J

出版信息

Laryngol Rhinol Otol (Stuttg). 1986 Mar;65(3):127-9.

PMID:3713388
Abstract

Extramedullary plasmocytomas of the salivary glands are extremely rare. Not more than four cases have been described in the literature. A further case of an extended extramedullary plasmocytoma of the parotid gland is presented. Radiotherapy of 40 Gy was sufficient for a complete remission of this tumour. Only three months later, however, the patient developed multiple medullary plasmocytoma, which could not be influenced by cytostatic drug treatment. Twelve months after diagnosis, the patient died from medullary plasmocytoma, but without any signs of local recurrence in the parotid gland. The prognosis of extramedullary plasmocytomas of the salivary glands seems to be poor, as about half of the presented cases developed multiple medullary plasmocytoma. Local recurrence at the primary site, however, was not seen in any case. Surgical treatment of extramedullary plasmocytomas of the salivary of extramedullary plasmocytomas of the salivary glands is recommended for those cases where complete removal of the tumour masses seems possible without greater functional damage. Extended plasmocytomas, especially of the parotid gland, should be treated by radiotherapy. They have an excellent radiosensitivity, and the high risk of multiple medullary plasmocytoma in these cases does not seem to justify a mutilating surgery including hemimandibulectomy or sacrifice of the facial nerve.

摘要

涎腺髓外浆细胞瘤极为罕见。文献中报道的病例不超过4例。本文报告1例腮腺广泛性髓外浆细胞瘤。40 Gy的放射治疗足以使该肿瘤完全缓解。然而,仅3个月后,患者就出现了多发性骨髓瘤样浆细胞瘤,细胞毒性药物治疗对此无效。诊断后12个月,患者死于骨髓瘤样浆细胞瘤,但腮腺无局部复发迹象。涎腺髓外浆细胞瘤的预后似乎较差,因为约一半的病例会发展为多发性骨髓瘤样浆细胞瘤。然而,在任何病例中均未观察到原发部位的局部复发。对于那些似乎可以在不造成更大功能损害的情况下完全切除肿瘤肿块的涎腺髓外浆细胞瘤病例,建议进行手术治疗。广泛性浆细胞瘤,尤其是腮腺的浆细胞瘤,应采用放射治疗。它们具有极好的放射敏感性,而且在这些病例中多发性骨髓瘤样浆细胞瘤的高风险似乎并不足以证明包括半侧下颌骨切除术或牺牲面神经在内的致残性手术是合理的。

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