成年大鼠肝细胞原代培养物中S-腺苷甲硫氨酸合成酶同工酶的诱导
Induction of S-adenosylmethionine synthetase isozymes in primary cultures of adult rat hepatocytes.
作者信息
Sawai Y, Suma Y, Tsukada K
出版信息
Life Sci. 1986 May 26;38(21):1975-80. doi: 10.1016/0024-3205(86)90227-4.
PMID:3713433
Abstract
The activities of S-adenosylmethionine synthetase isozymes were studied using adult rat hepatocytes in primary culture. Hepatocytes from adult rats were isolated and cultured for several days. The activities of the synthetase isozymes did not change during primary culture. The activity of the alpha-form increased with increasing ethionine plus adenine or methionine in the medium, and reached about 5 fold after 2 days. However, the increased activity of the beta-form showed less than twice.
摘要
利用原代培养的成年大鼠肝细胞研究了S-腺苷甲硫氨酸合成酶同工酶的活性。分离成年大鼠的肝细胞并培养数天。在原代培养期间，合成酶同工酶的活性没有变化。α型同工酶的活性随着培养基中乙硫氨酸加腺嘌呤或甲硫氨酸的增加而增加，2天后达到约5倍。然而，β型同工酶活性的增加不到两倍。
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