基于 AlGaN/GaN 高电子迁移率晶体管的癌胚抗原高灵敏度传感器。
A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors.
机构信息
Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, Jiangsu, People's Republic of China.
School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, People's Republic of China.
出版信息
Nanotechnology. 2023 May 18;34(31). doi: 10.1088/1361-6528/acd1f2.
Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg mlin phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.
癌胚抗原（CEA）是一种著名的生物标志物和已验证的肺癌血清生物标志物。我们介绍了一种用于 CEA 检测的简单无标记方法。通过将 CEA 抗体固定在 AlGaN/GaN 高电子迁移率晶体管的传感区域中，实现了对 CEA 的特异性识别。生物传感器在磷酸盐缓冲溶液中的检测限为 1 fg/ml。与其他肺癌检测方法相比，这种方法具有集成化、小型化、低成本和快速检测的优点，可用于未来的医学诊断。
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