用于远程近红外光控透皮药物递送的纳米结构壳聚糖-多酚贴片。
Nanostructured chitosan-polyphenolic patch for remote NIR-photothermal controlled dermal drug delivery.
机构信息
Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh.
出版信息
Int J Biol Macromol. 2023 Jun 30;241:124701. doi: 10.1016/j.ijbiomac.2023.124701. Epub 2023 May 1.
We describe the synthesis of a nanostructured dermal patch composed of chitosan-tannic acid (CT) that can carry near-infrared (NIR) active Indocyanine green (ICG) dye for performing photothermal heat conversion activity. The NIR-responsive CT-I dermal patch can deliver topical antibiotic drugs (Neomycin). The CT-I and drug-loaded CT-I/N patches have been demonstrated by FTIR, SEM/EDX, TGA, and DSC analysis. The in vitro drug release from the CT-I/N patch are favorable in the dermal environment (pH = 5.5) and significantly increases 25 % more at higher temperatures of 40 to 45 °C. The CT-I/N showed increasing photothermal heat in response to NIR (808 nm) light. The in vivo thermograph demonstrated that the CT-I/N patch can generate >45 °C within 5 min NIR irradiation. As a result, sustained wound healing was shown in H&E (hematoxylin and eosin) staining dermal tissue. Such NIR-active nanostructure film/patch is promising for the future of any sustained on-demand drug delivery system.
我们描述了一种由壳聚糖-鞣酸（CT）组成的纳米结构皮肤贴剂的合成，该贴剂可以携带近红外（NIR）活性吲哚菁绿（ICG）染料，以进行光热转换活性。NIR 响应的 CT-I 皮肤贴剂可以输送局部抗生素药物（新霉素）。FTIR、SEM/EDX、TGA 和 DSC 分析表明，CT-I 和载药 CT-I/N 贴片具有良好的体外药物释放性能，在皮肤环境（pH = 5.5）中，药物释放率显著提高了 25%，在 40 至 45°C 的较高温度下提高了 25%。CT-I/N 对 NIR（808nm）光表现出增强的光热性能。体内热成像图表明，CT-I/N 贴片在 5 分钟内接受 NIR 照射后，可产生超过 45°C 的温度。结果表明，H&E（苏木精和伊红）染色的皮肤组织中显示出持续的伤口愈合。这种 NIR 活性纳米结构薄膜/贴片有望成为未来任何按需持续药物输送系统的理想选择。
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