Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh.
Int J Biol Macromol. 2023 Jun 30;241:124701. doi: 10.1016/j.ijbiomac.2023.124701. Epub 2023 May 1.
We describe the synthesis of a nanostructured dermal patch composed of chitosan-tannic acid (CT) that can carry near-infrared (NIR) active Indocyanine green (ICG) dye for performing photothermal heat conversion activity. The NIR-responsive CT-I dermal patch can deliver topical antibiotic drugs (Neomycin). The CT-I and drug-loaded CT-I/N patches have been demonstrated by FTIR, SEM/EDX, TGA, and DSC analysis. The in vitro drug release from the CT-I/N patch are favorable in the dermal environment (pH = 5.5) and significantly increases 25 % more at higher temperatures of 40 to 45 °C. The CT-I/N showed increasing photothermal heat in response to NIR (808 nm) light. The in vivo thermograph demonstrated that the CT-I/N patch can generate >45 °C within 5 min NIR irradiation. As a result, sustained wound healing was shown in H&E (hematoxylin and eosin) staining dermal tissue. Such NIR-active nanostructure film/patch is promising for the future of any sustained on-demand drug delivery system.
我们描述了一种由壳聚糖-鞣酸（CT）组成的纳米结构皮肤贴剂的合成，该贴剂可以携带近红外（NIR）活性吲哚菁绿（ICG）染料，以进行光热转换活性。NIR 响应的 CT-I 皮肤贴剂可以输送局部抗生素药物（新霉素）。FTIR、SEM/EDX、TGA 和 DSC 分析表明，CT-I 和载药 CT-I/N 贴片具有良好的体外药物释放性能，在皮肤环境（pH = 5.5）中，药物释放率显著提高了 25%，在 40 至 45°C 的较高温度下提高了 25%。CT-I/N 对 NIR（808nm）光表现出增强的光热性能。体内热成像图表明，CT-I/N 贴片在 5 分钟内接受 NIR 照射后，可产生超过 45°C 的温度。结果表明，H&E（苏木精和伊红）染色的皮肤组织中显示出持续的伤口愈合。这种 NIR 活性纳米结构薄膜/贴片有望成为未来任何按需持续药物输送系统的理想选择。
